| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| GLI1 | GLI2 | ENSPPYP00000005342 | ENSPPYP00000014260 | GLI family zinc finger 1. | GLI2 isoform 1. | 0.991 |
| GLI1 | GLI3 | ENSPPYP00000005342 | ENSPPYP00000019741 | GLI family zinc finger 1. | GLI3 isoform 3. | 0.987 |
| GLI1 | SUFU | ENSPPYP00000005342 | ENSPPYP00000003030 | GLI family zinc finger 1. | Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] | 0.999 |
| GLI1 | ULK3 | ENSPPYP00000005342 | ENSPPYP00000007541 | GLI family zinc finger 1. | Unc-51 like kinase 3. | 0.918 |
| GLI2 | GLI1 | ENSPPYP00000014260 | ENSPPYP00000005342 | GLI2 isoform 1. | GLI family zinc finger 1. | 0.991 |
| GLI2 | GLI3 | ENSPPYP00000014260 | ENSPPYP00000019741 | GLI2 isoform 1. | GLI3 isoform 3. | 0.984 |
| GLI2 | SUFU | ENSPPYP00000014260 | ENSPPYP00000003030 | GLI2 isoform 1. | Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] | 0.999 |
| GLI2 | ULK3 | ENSPPYP00000014260 | ENSPPYP00000007541 | GLI2 isoform 1. | Unc-51 like kinase 3. | 0.911 |
| GLI3 | GLI1 | ENSPPYP00000019741 | ENSPPYP00000005342 | GLI3 isoform 3. | GLI family zinc finger 1. | 0.987 |
| GLI3 | GLI2 | ENSPPYP00000019741 | ENSPPYP00000014260 | GLI3 isoform 3. | GLI2 isoform 1. | 0.984 |
| GLI3 | SUFU | ENSPPYP00000019741 | ENSPPYP00000003030 | GLI3 isoform 3. | Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] | 0.999 |
| GLI3 | ULK3 | ENSPPYP00000019741 | ENSPPYP00000007541 | GLI3 isoform 3. | Unc-51 like kinase 3. | 0.757 |
| IST1 | ULK3 | ENSPPYP00000008494 | ENSPPYP00000007541 | IST1 homolog; ESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing. Regulates early endosomal tubulation together wi [...] | Unc-51 like kinase 3. | 0.784 |
| PIK3C3 | PIK3R4 | ENSPPYP00000010247 | ENSPPYP00000015770 | Phosphatidylinositol 3-kinase catalytic subunit type 3. | Phosphoinositide 3-kinase regulatory subunit 4; Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (By similarity). | 0.999 |
| PIK3C3 | RB1CC1 | ENSPPYP00000010247 | ENSPPYP00000020840 | Phosphatidylinositol 3-kinase catalytic subunit type 3. | RB1CC1 isoform 1. | 0.992 |
| PIK3C3 | ULK1 | ENSPPYP00000010247 | ENSPPYP00000005848 | Phosphatidylinositol 3-kinase catalytic subunit type 3. | Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. | 0.972 |
| PIK3C3 | ULK2 | ENSPPYP00000010247 | ENSPPYP00000009920 | Phosphatidylinositol 3-kinase catalytic subunit type 3. | Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. | 0.961 |
| PIK3C3 | ULK3 | ENSPPYP00000010247 | ENSPPYP00000007541 | Phosphatidylinositol 3-kinase catalytic subunit type 3. | Unc-51 like kinase 3. | 0.733 |
| PIK3R4 | PIK3C3 | ENSPPYP00000015770 | ENSPPYP00000010247 | Phosphoinositide 3-kinase regulatory subunit 4; Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (By similarity). | Phosphatidylinositol 3-kinase catalytic subunit type 3. | 0.999 |
| PIK3R4 | RB1CC1 | ENSPPYP00000015770 | ENSPPYP00000020840 | Phosphoinositide 3-kinase regulatory subunit 4; Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (By similarity). | RB1CC1 isoform 1. | 0.991 |
