STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NRG4NRG4 isoform 5. (115 aa)    
Predicted Functional Partners:
ERBB4
Receptor protein-tyrosine kinase.
   
 0.992
NRG1
NRG1 isoform 10.
    
 0.972
NRG2
NRG2 isoform 2.
    
 0.945
ERBB3
Receptor tyrosine-protein kinase erbB-3; Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation.
   
 0.844
FANCM
FANCM isoform 2.
   
 0.780
EGFR
Receptor protein-tyrosine kinase.
   
 0.755
PRDM10
PR domain zinc finger protein 10; May be involved in transcriptional regulation.
    
 0.748
ERBB2
Receptor protein-tyrosine kinase.
   
 0.740
SNAI2
Snail family transcriptional repressor 2.
      
 0.715
CITED2
Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2.
      
 0.702
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
Server load: medium (52%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.