| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CR201_G0028793 | CYP17A1 | ENSPPYP00000007772 | ENSPPYP00000003038 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | CYP17A1 isoform 1; Belongs to the cytochrome P450 family. | 0.950 |
| CR201_G0028793 | CYP21A2 | ENSPPYP00000007772 | ENSPPYP00000018425 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | CYP21A2 isoform 1; Belongs to the cytochrome P450 family. | 0.948 |
| CR201_G0028793 | CYP7B1 | ENSPPYP00000007772 | ENSPPYP00000020894 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. | 0.970 |
| CR201_G0028793 | DHCR24 | ENSPPYP00000007772 | ENSPPYP00000001525 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | DHCR24 isoform 1. | 0.826 |
| CR201_G0028793 | DHCR7 | ENSPPYP00000007772 | ENSPPYP00000003422 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | DHCR7 isoform 1. | 0.850 |
| CR201_G0028793 | FDX1 | ENSPPYP00000007772 | ENSPPYP00000004413 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | FDX1 isoform 1. | 0.934 |
| CR201_G0028793 | FDXR | ENSPPYP00000007772 | ENSPPYP00000009667 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | NADPH:adrenodoxin oxidoreductase, mitochondrial. | 0.868 |
| CR201_G0028793 | HSD3B1 | ENSPPYP00000007772 | ENSPPYP00000001124 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | HSD3B1 isoform 1; Belongs to the 3-beta-HSD family. | 0.977 |
| CR201_G0028793 | STAR | ENSPPYP00000007772 | ENSPPYP00000020760 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. | 0.822 |
| CR201_G0028793 | STS | ENSPPYP00000007772 | ENSPPYP00000022489 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | STS isoform 1. | 0.910 |
| CYP17A1 | CR201_G0028793 | ENSPPYP00000003038 | ENSPPYP00000007772 | CYP17A1 isoform 1; Belongs to the cytochrome P450 family. | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | 0.950 |
| CYP17A1 | CYP21A2 | ENSPPYP00000003038 | ENSPPYP00000018425 | CYP17A1 isoform 1; Belongs to the cytochrome P450 family. | CYP21A2 isoform 1; Belongs to the cytochrome P450 family. | 0.928 |
| CYP17A1 | CYP7B1 | ENSPPYP00000003038 | ENSPPYP00000020894 | CYP17A1 isoform 1; Belongs to the cytochrome P450 family. | Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. | 0.925 |
| CYP17A1 | FDX1 | ENSPPYP00000003038 | ENSPPYP00000004413 | CYP17A1 isoform 1; Belongs to the cytochrome P450 family. | FDX1 isoform 1. | 0.504 |
| CYP17A1 | HSD3B1 | ENSPPYP00000003038 | ENSPPYP00000001124 | CYP17A1 isoform 1; Belongs to the cytochrome P450 family. | HSD3B1 isoform 1; Belongs to the 3-beta-HSD family. | 0.979 |
| CYP17A1 | STAR | ENSPPYP00000003038 | ENSPPYP00000020760 | CYP17A1 isoform 1; Belongs to the cytochrome P450 family. | Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. | 0.818 |
| CYP17A1 | STS | ENSPPYP00000003038 | ENSPPYP00000022489 | CYP17A1 isoform 1; Belongs to the cytochrome P450 family. | STS isoform 1. | 0.917 |
| CYP21A2 | CR201_G0028793 | ENSPPYP00000018425 | ENSPPYP00000007772 | CYP21A2 isoform 1; Belongs to the cytochrome P450 family. | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | 0.948 |
| CYP21A2 | CYP17A1 | ENSPPYP00000018425 | ENSPPYP00000003038 | CYP21A2 isoform 1; Belongs to the cytochrome P450 family. | CYP17A1 isoform 1; Belongs to the cytochrome P450 family. | 0.928 |
| CYP21A2 | CYP7B1 | ENSPPYP00000018425 | ENSPPYP00000020894 | CYP21A2 isoform 1; Belongs to the cytochrome P450 family. | Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. | 0.931 |
