STUB1 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATXN3	STUB1	ENSPPYP00000006907	ENSPPYP00000007837	ATXN3 isoform 7.	STIP1 homology and U-box containing protein 1.	0.936
BAG1	DKFZp468G2216	ENSPPYP00000021443	ENSPPYP00000022865	BAG1 isoform 2.	AR isoform 8.	0.759
BAG1	HSPA4	ENSPPYP00000021443	ENSPPYP00000017643	BAG1 isoform 2.	Heat shock 70 kDa protein 4; Belongs to the heat shock protein 70 family.	0.974
BAG1	STUB1	ENSPPYP00000021443	ENSPPYP00000007837	BAG1 isoform 2.	STIP1 homology and U-box containing protein 1.	0.945
CFTR	HSP90AB1	ENSPPYP00000020117	ENSPPYP00000018631	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...]	Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...]	0.666
CFTR	HSPA4	ENSPPYP00000020117	ENSPPYP00000017643	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...]	Heat shock 70 kDa protein 4; Belongs to the heat shock protein 70 family.	0.838
CFTR	STUB1	ENSPPYP00000020117	ENSPPYP00000007837	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...]	STIP1 homology and U-box containing protein 1.	0.953
DKFZp468G2216	BAG1	ENSPPYP00000022865	ENSPPYP00000021443	AR isoform 8.	BAG1 isoform 2.	0.759
DKFZp468G2216	EGFR	ENSPPYP00000022865	ENSPPYP00000019671	AR isoform 8.	Receptor protein-tyrosine kinase.	0.769
DKFZp468G2216	ERBB2	ENSPPYP00000022865	ENSPPYP00000009527	AR isoform 8.	Receptor protein-tyrosine kinase.	0.651
DKFZp468G2216	HSP90AB1	ENSPPYP00000022865	ENSPPYP00000018631	AR isoform 8.	Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...]	0.982
DKFZp468G2216	HSPA4	ENSPPYP00000022865	ENSPPYP00000017643	AR isoform 8.	Heat shock 70 kDa protein 4; Belongs to the heat shock protein 70 family.	0.624
DKFZp468G2216	SMAD3	ENSPPYP00000022865	ENSPPYP00000007465	AR isoform 8.	Mothers against decapentaplegic homolog.	0.805
DKFZp468G2216	STUB1	ENSPPYP00000022865	ENSPPYP00000007837	AR isoform 8.	STIP1 homology and U-box containing protein 1.	0.930
DKFZp468G2216	TP53	ENSPPYP00000022865	ENSPPYP00000008923	AR isoform 8.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.731
EGFR	DKFZp468G2216	ENSPPYP00000019671	ENSPPYP00000022865	Receptor protein-tyrosine kinase.	AR isoform 8.	0.769
EGFR	ERBB2	ENSPPYP00000019671	ENSPPYP00000009527	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.996
EGFR	HSP90AB1	ENSPPYP00000019671	ENSPPYP00000018631	Receptor protein-tyrosine kinase.	Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...]	0.964
EGFR	HSPA4	ENSPPYP00000019671	ENSPPYP00000017643	Receptor protein-tyrosine kinase.	Heat shock 70 kDa protein 4; Belongs to the heat shock protein 70 family.	0.936
EGFR	STUB1	ENSPPYP00000019671	ENSPPYP00000007837	Receptor protein-tyrosine kinase.	STIP1 homology and U-box containing protein 1.	0.948