| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CR201_G0007169 | CR201_G0054913 | ENSPPYP00000000742 | ENSPPYP00000013536 | SUMO1 isoform 5. | RGPD3 isoform 1. | 0.722 |
| CR201_G0007169 | PIAS1 | ENSPPYP00000000742 | ENSPPYP00000007471 | SUMO1 isoform 5. | PIAS1 isoform 1. | 0.957 |
| CR201_G0007169 | PIAS2 | ENSPPYP00000000742 | ENSPPYP00000010266 | SUMO1 isoform 5. | Protein inhibitor of activated STAT 2. | 0.937 |
| CR201_G0007169 | PIAS4 | ENSPPYP00000000742 | ENSPPYP00000010535 | SUMO1 isoform 5. | PIAS4 isoform 1. | 0.989 |
| CR201_G0007169 | PML | ENSPPYP00000000742 | ENSPPYP00000007521 | SUMO1 isoform 5. | PML isoform 4. | 0.858 |
| CR201_G0007169 | RANGAP1 | ENSPPYP00000000742 | ENSPPYP00000013240 | SUMO1 isoform 5. | RANGAP1 isoform 1. | 0.940 |
| CR201_G0007169 | SAE1 | ENSPPYP00000000742 | ENSPPYP00000011372 | SUMO1 isoform 5. | SUMO-activating enzyme subunit 1, N-terminally processed; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity); Belongs to the ubiquitin-activating E1 family. | 0.946 |
| CR201_G0007169 | SUMO1 | ENSPPYP00000000742 | ENSPPYP00000014619 | SUMO1 isoform 5. | Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for insta [...] | 0.801 |
| CR201_G0007169 | UBA2 | ENSPPYP00000000742 | ENSPPYP00000011014 | SUMO1 isoform 5. | SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. | 0.972 |
| CR201_G0007169 | UBE2I | ENSPPYP00000000742 | ENSPPYP00000007864 | SUMO1 isoform 5. | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. | 0.978 |
| CR201_G0054913 | CR201_G0007169 | ENSPPYP00000013536 | ENSPPYP00000000742 | RGPD3 isoform 1. | SUMO1 isoform 5. | 0.722 |
| CR201_G0054913 | RANGAP1 | ENSPPYP00000013536 | ENSPPYP00000013240 | RGPD3 isoform 1. | RANGAP1 isoform 1. | 0.989 |
| CR201_G0054913 | SAE1 | ENSPPYP00000013536 | ENSPPYP00000011372 | RGPD3 isoform 1. | SUMO-activating enzyme subunit 1, N-terminally processed; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity); Belongs to the ubiquitin-activating E1 family. | 0.558 |
| CR201_G0054913 | SUMO1 | ENSPPYP00000013536 | ENSPPYP00000014619 | RGPD3 isoform 1. | Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for insta [...] | 0.722 |
| CR201_G0054913 | UBA2 | ENSPPYP00000013536 | ENSPPYP00000011014 | RGPD3 isoform 1. | SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. | 0.500 |
| CR201_G0054913 | UBE2I | ENSPPYP00000013536 | ENSPPYP00000007864 | RGPD3 isoform 1. | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. | 0.985 |
| PIAS1 | CR201_G0007169 | ENSPPYP00000007471 | ENSPPYP00000000742 | PIAS1 isoform 1. | SUMO1 isoform 5. | 0.957 |
| PIAS1 | PIAS2 | ENSPPYP00000007471 | ENSPPYP00000010266 | PIAS1 isoform 1. | Protein inhibitor of activated STAT 2. | 0.702 |
| PIAS1 | PIAS4 | ENSPPYP00000007471 | ENSPPYP00000010535 | PIAS1 isoform 1. | PIAS4 isoform 1. | 0.652 |
| PIAS1 | SAE1 | ENSPPYP00000007471 | ENSPPYP00000011372 | PIAS1 isoform 1. | SUMO-activating enzyme subunit 1, N-terminally processed; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity); Belongs to the ubiquitin-activating E1 family. | 0.532 |
