MLST8 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

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co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1S1	ATG13	ENSPPYP00000011493	ENSPPYP00000003811	AKT1S1 isoform 1.	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity).	0.945
AKT1S1	EIF4EBP1	ENSPPYP00000011493	ENSPPYP00000020757	AKT1S1 isoform 1.	Eukaryotic translation initiation factor 4E binding protein 1.	0.980
AKT1S1	MAPKAP1	ENSPPYP00000011493	ENSPPYP00000021975	AKT1S1 isoform 1.	Target of rapamycin complex 2 subunit MAPKAP1; Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the [...]	0.893
AKT1S1	MLST8	ENSPPYP00000011493	ENSPPYP00000007913	AKT1S1 isoform 1.	MTOR associated protein, LST8 homolog.	0.997
AKT1S1	RHEB	ENSPPYP00000011493	ENSPPYP00000020403	AKT1S1 isoform 1.	RHEB isoform 1.	0.986
AKT1S1	RICTOR	ENSPPYP00000011493	ENSPPYP00000017219	AKT1S1 isoform 1.	RICTOR isoform 1.	0.526
AKT1S1	RPTOR	ENSPPYP00000011493	ENSPPYP00000024617	AKT1S1 isoform 1.	RPTOR isoform 4.	0.999
AKT1S1	RRAGA	ENSPPYP00000011493	ENSPPYP00000021503	AKT1S1 isoform 1.	Ras related GTP binding A.	0.980
AKT1S1	RRAGC	ENSPPYP00000011493	ENSPPYP00000001752	AKT1S1 isoform 1.	RRAGC isoform 1.	0.986
AKT1S1	RRAGD	ENSPPYP00000011493	ENSPPYP00000018853	AKT1S1 isoform 1.	RRAGD isoform 1.	0.982
ATG13	AKT1S1	ENSPPYP00000003811	ENSPPYP00000011493	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity).	AKT1S1 isoform 1.	0.945
ATG13	MLST8	ENSPPYP00000003811	ENSPPYP00000007913	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity).	MTOR associated protein, LST8 homolog.	0.987
ATG13	RHEB	ENSPPYP00000003811	ENSPPYP00000020403	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity).	RHEB isoform 1.	0.589
ATG13	RPTOR	ENSPPYP00000003811	ENSPPYP00000024617	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity).	RPTOR isoform 4.	0.992
ATG13	RRAGA	ENSPPYP00000003811	ENSPPYP00000021503	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity).	Ras related GTP binding A.	0.624
ATG13	RRAGC	ENSPPYP00000003811	ENSPPYP00000001752	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity).	RRAGC isoform 1.	0.605
ATG13	RRAGD	ENSPPYP00000003811	ENSPPYP00000018853	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity).	RRAGD isoform 1.	0.605
EIF4EBP1	AKT1S1	ENSPPYP00000020757	ENSPPYP00000011493	Eukaryotic translation initiation factor 4E binding protein 1.	AKT1S1 isoform 1.	0.980
EIF4EBP1	MAPKAP1	ENSPPYP00000020757	ENSPPYP00000021975	Eukaryotic translation initiation factor 4E binding protein 1.	Target of rapamycin complex 2 subunit MAPKAP1; Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the [...]	0.456
EIF4EBP1	MLST8	ENSPPYP00000020757	ENSPPYP00000007913	Eukaryotic translation initiation factor 4E binding protein 1.	MTOR associated protein, LST8 homolog.	0.993