MEFV protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP1	CASP8	ENSPPYP00000004375	ENSPPYP00000014605	CASP1 isoform 4; Belongs to the peptidase C14A family.	CASP8 isoform 1; Belongs to the peptidase C14A family.	0.971
CASP1	FADD	ENSPPYP00000004375	ENSPPYP00000003427	CASP1 isoform 4; Belongs to the peptidase C14A family.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.915
CASP1	MEFV	ENSPPYP00000004375	ENSPPYP00000007958	CASP1 isoform 4; Belongs to the peptidase C14A family.	MEFV isoform 4.	0.992
CASP1	PKN2	ENSPPYP00000004375	ENSPPYP00000001367	CASP1 isoform 4; Belongs to the peptidase C14A family.	PKN2 isoform 1.	0.478
CASP1	PSTPIP1	ENSPPYP00000004375	ENSPPYP00000007578	CASP1 isoform 4; Belongs to the peptidase C14A family.	PSTPIP1 isoform 5.	0.413
CASP1	PYCARD	ENSPPYP00000004375	ENSPPYP00000008260	CASP1 isoform 4; Belongs to the peptidase C14A family.	PYD and CARD domain containing.	0.999
CASP1	RIPK1	ENSPPYP00000004375	ENSPPYP00000018096	CASP1 isoform 4; Belongs to the peptidase C14A family.	Receptor interacting serine/threonine kinase 1.	0.902
CASP1	RIPK3	ENSPPYP00000004375	ENSPPYP00000006485	CASP1 isoform 4; Belongs to the peptidase C14A family.	Receptor interacting serine/threonine kinase 3.	0.910
CASP8	CASP1	ENSPPYP00000014605	ENSPPYP00000004375	CASP8 isoform 1; Belongs to the peptidase C14A family.	CASP1 isoform 4; Belongs to the peptidase C14A family.	0.971
CASP8	FADD	ENSPPYP00000014605	ENSPPYP00000003427	CASP8 isoform 1; Belongs to the peptidase C14A family.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.999
CASP8	MEFV	ENSPPYP00000014605	ENSPPYP00000007958	CASP8 isoform 1; Belongs to the peptidase C14A family.	MEFV isoform 4.	0.922
CASP8	PYCARD	ENSPPYP00000014605	ENSPPYP00000008260	CASP8 isoform 1; Belongs to the peptidase C14A family.	PYD and CARD domain containing.	0.991
CASP8	RIPK1	ENSPPYP00000014605	ENSPPYP00000018096	CASP8 isoform 1; Belongs to the peptidase C14A family.	Receptor interacting serine/threonine kinase 1.	0.999
CASP8	RIPK3	ENSPPYP00000014605	ENSPPYP00000006485	CASP8 isoform 1; Belongs to the peptidase C14A family.	Receptor interacting serine/threonine kinase 3.	0.998
FADD	CASP1	ENSPPYP00000003427	ENSPPYP00000004375	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	CASP1 isoform 4; Belongs to the peptidase C14A family.	0.915
FADD	CASP8	ENSPPYP00000003427	ENSPPYP00000014605	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	CASP8 isoform 1; Belongs to the peptidase C14A family.	0.999
FADD	MEFV	ENSPPYP00000003427	ENSPPYP00000007958	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	MEFV isoform 4.	0.915
FADD	PYCARD	ENSPPYP00000003427	ENSPPYP00000008260	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	PYD and CARD domain containing.	0.830
FADD	RIPK1	ENSPPYP00000003427	ENSPPYP00000018096	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Receptor interacting serine/threonine kinase 1.	0.999
FADD	RIPK3	ENSPPYP00000003427	ENSPPYP00000006485	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Receptor interacting serine/threonine kinase 3.	0.995