| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EIF4A3 | ETF1 | ENSPPYP00000009779 | ENSPPYP00000017698 | Eukaryotic translation initiation factor 4A3; Belongs to the DEAD box helicase family. | Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes. | 0.476 |
| EIF4A3 | NCBP2 | ENSPPYP00000009779 | ENSPPYP00000016158 | Eukaryotic translation initiation factor 4A3; Belongs to the DEAD box helicase family. | Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...] | 0.923 |
| EIF4A3 | PABPC1 | ENSPPYP00000009779 | ENSPPYP00000021076 | Eukaryotic translation initiation factor 4A3; Belongs to the DEAD box helicase family. | Polyadenylate-binding protein 1; Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region deter [...] | 0.833 |
| EIF4A3 | RBM8A | ENSPPYP00000009779 | ENSPPYP00000001082 | Eukaryotic translation initiation factor 4A3; Belongs to the DEAD box helicase family. | RNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. | 0.991 |
| EIF4A3 | SMG1 | ENSPPYP00000009779 | ENSPPYP00000008072 | Eukaryotic translation initiation factor 4A3; Belongs to the DEAD box helicase family. | SMG1 isoform 8; Belongs to the PI3/PI4-kinase family. | 0.949 |
| EIF4A3 | SMG7 | ENSPPYP00000009779 | ENSPPYP00000000485 | Eukaryotic translation initiation factor 4A3; Belongs to the DEAD box helicase family. | SMG7 nonsense mediated mRNA decay factor. | 0.637 |
| EIF4A3 | SMG8 | ENSPPYP00000009779 | ENSPPYP00000009242 | Eukaryotic translation initiation factor 4A3; Belongs to the DEAD box helicase family. | Protein SMG8. | 0.485 |
| EIF4A3 | SMG9 | ENSPPYP00000009779 | ENSPPYP00000023744 | Eukaryotic translation initiation factor 4A3; Belongs to the DEAD box helicase family. | SMG9 nonsense mediated mRNA decay factor. | 0.484 |
| EIF4A3 | UPF1 | ENSPPYP00000009779 | ENSPPYP00000010923 | Eukaryotic translation initiation factor 4A3; Belongs to the DEAD box helicase family. | UPF1 isoform 2. | 0.991 |
| EIF4A3 | UPF2 | ENSPPYP00000009779 | ENSPPYP00000002423 | Eukaryotic translation initiation factor 4A3; Belongs to the DEAD box helicase family. | UPF2 isoform 1. | 0.972 |
| ETF1 | EIF4A3 | ENSPPYP00000017698 | ENSPPYP00000009779 | Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes. | Eukaryotic translation initiation factor 4A3; Belongs to the DEAD box helicase family. | 0.476 |
| ETF1 | NCBP2 | ENSPPYP00000017698 | ENSPPYP00000016158 | Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes. | Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...] | 0.617 |
| ETF1 | PABPC1 | ENSPPYP00000017698 | ENSPPYP00000021076 | Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes. | Polyadenylate-binding protein 1; Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region deter [...] | 0.618 |
| ETF1 | RBM8A | ENSPPYP00000017698 | ENSPPYP00000001082 | Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes. | RNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. | 0.644 |
| ETF1 | SMG1 | ENSPPYP00000017698 | ENSPPYP00000008072 | Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes. | SMG1 isoform 8; Belongs to the PI3/PI4-kinase family. | 0.965 |
| ETF1 | SMG7 | ENSPPYP00000017698 | ENSPPYP00000000485 | Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes. | SMG7 nonsense mediated mRNA decay factor. | 0.463 |
| ETF1 | SMG8 | ENSPPYP00000017698 | ENSPPYP00000009242 | Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes. | Protein SMG8. | 0.516 |
| ETF1 | SMG9 | ENSPPYP00000017698 | ENSPPYP00000023744 | Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes. | SMG9 nonsense mediated mRNA decay factor. | 0.657 |
| ETF1 | UPF1 | ENSPPYP00000017698 | ENSPPYP00000010923 | Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes. | UPF1 isoform 2. | 0.929 |
| ETF1 | UPF2 | ENSPPYP00000017698 | ENSPPYP00000002423 | Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes. | UPF2 isoform 1. | 0.540 |
