| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACADS | ACAT1 | ENSPPYP00000005742 | ENSPPYP00000004400 | Short-chain specific acyl-CoA dehydrogenase, mitochondrial; Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, short-chai [...] | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | 0.955 |
| ACADS | ACSM5 | ENSPPYP00000005742 | ENSPPYP00000008092 | Short-chain specific acyl-CoA dehydrogenase, mitochondrial; Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, short-chai [...] | Acyl-CoA synthetase medium chain family member 5. | 0.928 |
| ACADS | ADHFE1 | ENSPPYP00000005742 | ENSPPYP00000020906 | Short-chain specific acyl-CoA dehydrogenase, mitochondrial; Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, short-chai [...] | Hydroxyacid-oxoacid transhydrogenase, mitochondrial; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2- KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity). | 0.558 |
| ACADS | ALDH5A1 | ENSPPYP00000005742 | ENSPPYP00000018204 | Short-chain specific acyl-CoA dehydrogenase, mitochondrial; Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, short-chai [...] | Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | 0.510 |
| ACADS | CS | ENSPPYP00000005742 | ENSPPYP00000005303 | Short-chain specific acyl-CoA dehydrogenase, mitochondrial; Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, short-chai [...] | Citrate synthase, mitochondrial isoform X1. | 0.469 |
| ACADS | HADHB | ENSPPYP00000005742 | ENSPPYP00000014050 | Short-chain specific acyl-CoA dehydrogenase, mitochondrial; Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, short-chai [...] | HADHB isoform 3; Belongs to the thiolase-like superfamily. Thiolase family. | 0.969 |
| ACADS | HSDL2 | ENSPPYP00000005742 | ENSPPYP00000021856 | Short-chain specific acyl-CoA dehydrogenase, mitochondrial; Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, short-chai [...] | Hydroxysteroid dehydrogenase-like protein 2; Has apparently no steroid dehydrogenase activity. Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.767 |
| ACAT1 | ACADS | ENSPPYP00000004400 | ENSPPYP00000005742 | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Short-chain specific acyl-CoA dehydrogenase, mitochondrial; Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, short-chai [...] | 0.955 |
| ACAT1 | ACSM5 | ENSPPYP00000004400 | ENSPPYP00000008092 | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Acyl-CoA synthetase medium chain family member 5. | 0.410 |
| ACAT1 | ALDH5A1 | ENSPPYP00000004400 | ENSPPYP00000018204 | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | 0.433 |
| ACAT1 | CS | ENSPPYP00000004400 | ENSPPYP00000005303 | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Citrate synthase, mitochondrial isoform X1. | 0.962 |
| ACAT1 | HADHB | ENSPPYP00000004400 | ENSPPYP00000014050 | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | HADHB isoform 3; Belongs to the thiolase-like superfamily. Thiolase family. | 0.958 |
| ACAT1 | HSDL2 | ENSPPYP00000004400 | ENSPPYP00000021856 | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Hydroxysteroid dehydrogenase-like protein 2; Has apparently no steroid dehydrogenase activity. Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.830 |
| ACSM5 | ACADS | ENSPPYP00000008092 | ENSPPYP00000005742 | Acyl-CoA synthetase medium chain family member 5. | Short-chain specific acyl-CoA dehydrogenase, mitochondrial; Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, short-chai [...] | 0.928 |
| ACSM5 | ACAT1 | ENSPPYP00000008092 | ENSPPYP00000004400 | Acyl-CoA synthetase medium chain family member 5. | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | 0.410 |
| ACSM5 | ADHFE1 | ENSPPYP00000008092 | ENSPPYP00000020906 | Acyl-CoA synthetase medium chain family member 5. | Hydroxyacid-oxoacid transhydrogenase, mitochondrial; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2- KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity). | 0.419 |
| ACSM5 | ALDH5A1 | ENSPPYP00000008092 | ENSPPYP00000018204 | Acyl-CoA synthetase medium chain family member 5. | Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | 0.422 |
| ACSM5 | CS | ENSPPYP00000008092 | ENSPPYP00000005303 | Acyl-CoA synthetase medium chain family member 5. | Citrate synthase, mitochondrial isoform X1. | 0.579 |
| ACSM5 | HADHB | ENSPPYP00000008092 | ENSPPYP00000014050 | Acyl-CoA synthetase medium chain family member 5. | HADHB isoform 3; Belongs to the thiolase-like superfamily. Thiolase family. | 0.412 |
| ACSM5 | HAO2 | ENSPPYP00000008092 | ENSPPYP00000001125 | Acyl-CoA synthetase medium chain family member 5. | HAO2 isoform 1. | 0.418 |
