| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DUSP1 | FOS | ENSPPYP00000017960 | ENSPPYP00000006826 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Fos proto-oncogene, AP-1 transcription factor subunit. | 0.941 |
| DUSP1 | MAPK3 | ENSPPYP00000017960 | ENSPPYP00000008184 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.992 |
| DUSP6 | MAPK3 | ENSPPYP00000005492 | ENSPPYP00000008184 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.996 |
| ELK1 | FOS | ENSPPYP00000023769 | ENSPPYP00000006826 | ETS transcription factor ELK1. | Fos proto-oncogene, AP-1 transcription factor subunit. | 0.538 |
| ELK1 | MAPK3 | ENSPPYP00000023769 | ENSPPYP00000008184 | ETS transcription factor ELK1. | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.995 |
| FOS | DUSP1 | ENSPPYP00000006826 | ENSPPYP00000017960 | Fos proto-oncogene, AP-1 transcription factor subunit. | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.941 |
| FOS | ELK1 | ENSPPYP00000006826 | ENSPPYP00000023769 | Fos proto-oncogene, AP-1 transcription factor subunit. | ETS transcription factor ELK1. | 0.538 |
| FOS | MAPK3 | ENSPPYP00000006826 | ENSPPYP00000008184 | Fos proto-oncogene, AP-1 transcription factor subunit. | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.989 |
| FOS | RPS6KA3 | ENSPPYP00000006826 | ENSPPYP00000022577 | Fos proto-oncogene, AP-1 transcription factor subunit. | Ribosomal protein S6 kinase. | 0.445 |
| FOS | TP53 | ENSPPYP00000006826 | ENSPPYP00000008923 | Fos proto-oncogene, AP-1 transcription factor subunit. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.627 |
| MAP2K1 | MAP2K2 | ENSPPYP00000007458 | ENSPPYP00000011850 | MAP2K1 isoform 1; Belongs to the protein kinase superfamily. | MAP2K2 isoform 6. | 0.999 |
| MAP2K1 | MAPK3 | ENSPPYP00000007458 | ENSPPYP00000008184 | MAP2K1 isoform 1; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.999 |
| MAP2K1 | TP53 | ENSPPYP00000007458 | ENSPPYP00000008923 | MAP2K1 isoform 1; Belongs to the protein kinase superfamily. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.441 |
| MAP2K2 | MAP2K1 | ENSPPYP00000011850 | ENSPPYP00000007458 | MAP2K2 isoform 6. | MAP2K1 isoform 1; Belongs to the protein kinase superfamily. | 0.999 |
| MAP2K2 | MAPK3 | ENSPPYP00000011850 | ENSPPYP00000008184 | MAP2K2 isoform 6. | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.990 |
| MAPK3 | DUSP1 | ENSPPYP00000008184 | ENSPPYP00000017960 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.992 |
| MAPK3 | DUSP6 | ENSPPYP00000008184 | ENSPPYP00000005492 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.996 |
| MAPK3 | ELK1 | ENSPPYP00000008184 | ENSPPYP00000023769 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | ETS transcription factor ELK1. | 0.995 |
| MAPK3 | FOS | ENSPPYP00000008184 | ENSPPYP00000006826 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | Fos proto-oncogene, AP-1 transcription factor subunit. | 0.989 |
| MAPK3 | MAP2K1 | ENSPPYP00000008184 | ENSPPYP00000007458 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | MAP2K1 isoform 1; Belongs to the protein kinase superfamily. | 0.999 |
