node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTR6 | DMAP1 | ENSPPYP00000005551 | ENSPPYP00000001660 | Actin related protein 6; Belongs to the actin family. | DNA methyltransferase 1 associated protein 1. | 0.912 |
ACTR6 | H2AZ1 | ENSPPYP00000005551 | ENSPPYP00000016702 | Actin related protein 6; Belongs to the actin family. | Histone H2A.Z; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for c [...] | 0.832 |
ACTR6 | RUVBL1 | ENSPPYP00000005551 | ENSPPYP00000015029 | Actin related protein 6; Belongs to the actin family. | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. | 0.913 |
ACTR6 | RUVBL2 | ENSPPYP00000005551 | ENSPPYP00000011437 | Actin related protein 6; Belongs to the actin family. | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. | 0.917 |
ACTR6 | SRCAP | ENSPPYP00000005551 | ENSPPYP00000008230 | Actin related protein 6; Belongs to the actin family. | T0121283 isoform 1. | 0.920 |
ACTR6 | VPS72 | ENSPPYP00000005551 | ENSPPYP00000001020 | Actin related protein 6; Belongs to the actin family. | Vacuolar protein sorting-associated protein 72 homolog; Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. | 0.830 |
ACTR6 | YEATS4 | ENSPPYP00000005551 | ENSPPYP00000005420 | Actin related protein 6; Belongs to the actin family. | YEATS domain containing 4. | 0.857 |
DMAP1 | ACTR6 | ENSPPYP00000001660 | ENSPPYP00000005551 | DNA methyltransferase 1 associated protein 1. | Actin related protein 6; Belongs to the actin family. | 0.912 |
DMAP1 | H2AZ1 | ENSPPYP00000001660 | ENSPPYP00000016702 | DNA methyltransferase 1 associated protein 1. | Histone H2A.Z; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for c [...] | 0.839 |
DMAP1 | KAT5 | ENSPPYP00000001660 | ENSPPYP00000003532 | DNA methyltransferase 1 associated protein 1. | Histone acetyltransferase KAT5; Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replica [...] | 0.996 |
DMAP1 | RUVBL1 | ENSPPYP00000001660 | ENSPPYP00000015029 | DNA methyltransferase 1 associated protein 1. | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. | 0.998 |
DMAP1 | RUVBL2 | ENSPPYP00000001660 | ENSPPYP00000011437 | DNA methyltransferase 1 associated protein 1. | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. | 0.997 |
DMAP1 | SRCAP | ENSPPYP00000001660 | ENSPPYP00000008230 | DNA methyltransferase 1 associated protein 1. | T0121283 isoform 1. | 0.931 |
DMAP1 | TRRAP | ENSPPYP00000001660 | ENSPPYP00000019457 | DNA methyltransferase 1 associated protein 1. | Transformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family. | 0.995 |
DMAP1 | VPS72 | ENSPPYP00000001660 | ENSPPYP00000001020 | DNA methyltransferase 1 associated protein 1. | Vacuolar protein sorting-associated protein 72 homolog; Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. | 0.996 |
DMAP1 | YEATS4 | ENSPPYP00000001660 | ENSPPYP00000005420 | DNA methyltransferase 1 associated protein 1. | YEATS domain containing 4. | 0.998 |
EP300 | H2AZ1 | ENSPPYP00000013236 | ENSPPYP00000016702 | EP300 isoform 1. | Histone H2A.Z; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for c [...] | 0.619 |
EP300 | KAT5 | ENSPPYP00000013236 | ENSPPYP00000003532 | EP300 isoform 1. | Histone acetyltransferase KAT5; Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replica [...] | 0.841 |
EP300 | RUVBL1 | ENSPPYP00000013236 | ENSPPYP00000015029 | EP300 isoform 1. | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. | 0.614 |
EP300 | RUVBL2 | ENSPPYP00000013236 | ENSPPYP00000011437 | EP300 isoform 1. | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. | 0.456 |