| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DNAJA1 | DNAJA2 | ENSPPYP00000021446 | ENSPPYP00000008269 | DnaJ homolog subfamily A member 1; Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity). | DnaJ heat shock protein family (Hsp40) member A2. | 0.802 |
| DNAJA1 | ENSPPYP00000005659 | ENSPPYP00000021446 | ENSPPYP00000005659 | DnaJ homolog subfamily A member 1; Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity). | annotation not available | 0.958 |
| DNAJA1 | HSPA1A | ENSPPYP00000021446 | ENSPPYP00000018408 | DnaJ homolog subfamily A member 1; Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity). | Heat shock 70 kDa protein 1; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP [...] | 0.871 |
| DNAJA1 | HSPA1L | ENSPPYP00000021446 | ENSPPYP00000018406 | DnaJ homolog subfamily A member 1; Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity). | Heat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. | 0.831 |
| DNAJA1 | HSPA2 | ENSPPYP00000021446 | ENSPPYP00000006709 | DnaJ homolog subfamily A member 1; Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity). | Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. | 0.818 |
| DNAJA1 | HSPA4 | ENSPPYP00000021446 | ENSPPYP00000017643 | DnaJ homolog subfamily A member 1; Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity). | Heat shock 70 kDa protein 4; Belongs to the heat shock protein 70 family. | 0.929 |
| DNAJA1 | HSPA5 | ENSPPYP00000021446 | ENSPPYP00000021973 | DnaJ homolog subfamily A member 1; Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity). | Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] | 0.814 |
| DNAJA1 | HSPA6 | ENSPPYP00000021446 | ENSPPYP00000000695 | DnaJ homolog subfamily A member 1; Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity). | Heat shock protein family A (Hsp70) member 6; Belongs to the heat shock protein 70 family. | 0.835 |
| DNAJA1 | HSPA8 | ENSPPYP00000021446 | ENSPPYP00000004564 | DnaJ homolog subfamily A member 1; Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity). | Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...] | 0.965 |
| DNAJA1 | STIP1 | ENSPPYP00000021446 | ENSPPYP00000003602 | DnaJ homolog subfamily A member 1; Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity). | STIP1 isoform 2. | 0.851 |
| DNAJA2 | DNAJA1 | ENSPPYP00000008269 | ENSPPYP00000021446 | DnaJ heat shock protein family (Hsp40) member A2. | DnaJ homolog subfamily A member 1; Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity). | 0.802 |
| DNAJA2 | ENSPPYP00000005659 | ENSPPYP00000008269 | ENSPPYP00000005659 | DnaJ heat shock protein family (Hsp40) member A2. | annotation not available | 0.935 |
| DNAJA2 | HSPA1A | ENSPPYP00000008269 | ENSPPYP00000018408 | DnaJ heat shock protein family (Hsp40) member A2. | Heat shock 70 kDa protein 1; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP [...] | 0.816 |
| DNAJA2 | HSPA1L | ENSPPYP00000008269 | ENSPPYP00000018406 | DnaJ heat shock protein family (Hsp40) member A2. | Heat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. | 0.831 |
| DNAJA2 | HSPA2 | ENSPPYP00000008269 | ENSPPYP00000006709 | DnaJ heat shock protein family (Hsp40) member A2. | Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. | 0.816 |
| DNAJA2 | HSPA4 | ENSPPYP00000008269 | ENSPPYP00000017643 | DnaJ heat shock protein family (Hsp40) member A2. | Heat shock 70 kDa protein 4; Belongs to the heat shock protein 70 family. | 0.818 |
| DNAJA2 | HSPA5 | ENSPPYP00000008269 | ENSPPYP00000021973 | DnaJ heat shock protein family (Hsp40) member A2. | Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] | 0.794 |
| DNAJA2 | HSPA6 | ENSPPYP00000008269 | ENSPPYP00000000695 | DnaJ heat shock protein family (Hsp40) member A2. | Heat shock protein family A (Hsp70) member 6; Belongs to the heat shock protein 70 family. | 0.812 |
| DNAJA2 | HSPA8 | ENSPPYP00000008269 | ENSPPYP00000004564 | DnaJ heat shock protein family (Hsp40) member A2. | Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...] | 0.947 |
| DNAJA2 | STIP1 | ENSPPYP00000008269 | ENSPPYP00000003602 | DnaJ heat shock protein family (Hsp40) member A2. | STIP1 isoform 2. | 0.799 |
STRING v12.5 is now available!
