node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTB | ACTL6A | ENSPPYP00000019427 | ENSPPYP00000016016 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | ACTL6A isoform 2; Belongs to the actin family. | 0.999 |
ACTB | ARID2 | ENSPPYP00000019427 | ENSPPYP00000005060 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | AT-rich interaction domain 2. | 0.970 |
ACTB | BRD7 | ENSPPYP00000019427 | ENSPPYP00000008289 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Bromodomain-containing protein 7; Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR. Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 [...] | 0.961 |
ACTB | DPF3 | ENSPPYP00000019427 | ENSPPYP00000006777 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | DPF3 isoform 1. | 0.819 |
ACTB | PBRM1 | ENSPPYP00000019427 | ENSPPYP00000024641 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | PBRM1 isoform 3. | 0.966 |
ACTB | PHF10 | ENSPPYP00000019427 | ENSPPYP00000019249 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | PHF10 isoform 1. | 0.977 |
ACTB | SMARCA4 | ENSPPYP00000019427 | ENSPPYP00000010731 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | SMARCA4 isoform 2. | 0.988 |
ACTB | SMARCB1 | ENSPPYP00000019427 | ENSPPYP00000012976 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. | 0.977 |
ACTB | SMARCC2 | ENSPPYP00000019427 | ENSPPYP00000005295 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | SMARCC2 isoform 7. | 0.974 |
ACTB | SMARCD1 | ENSPPYP00000019427 | ENSPPYP00000005143 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | SMARCD1 isoform 1. | 0.982 |
ACTL6A | ACTB | ENSPPYP00000016016 | ENSPPYP00000019427 | ACTL6A isoform 2; Belongs to the actin family. | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | 0.999 |
ACTL6A | ARID2 | ENSPPYP00000016016 | ENSPPYP00000005060 | ACTL6A isoform 2; Belongs to the actin family. | AT-rich interaction domain 2. | 0.990 |
ACTL6A | BRD7 | ENSPPYP00000016016 | ENSPPYP00000008289 | ACTL6A isoform 2; Belongs to the actin family. | Bromodomain-containing protein 7; Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR. Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 [...] | 0.989 |
ACTL6A | DPF3 | ENSPPYP00000016016 | ENSPPYP00000006777 | ACTL6A isoform 2; Belongs to the actin family. | DPF3 isoform 1. | 0.979 |
ACTL6A | PBRM1 | ENSPPYP00000016016 | ENSPPYP00000024641 | ACTL6A isoform 2; Belongs to the actin family. | PBRM1 isoform 3. | 0.993 |
ACTL6A | PHF10 | ENSPPYP00000016016 | ENSPPYP00000019249 | ACTL6A isoform 2; Belongs to the actin family. | PHF10 isoform 1. | 0.999 |
ACTL6A | SMARCA4 | ENSPPYP00000016016 | ENSPPYP00000010731 | ACTL6A isoform 2; Belongs to the actin family. | SMARCA4 isoform 2. | 0.997 |
ACTL6A | SMARCB1 | ENSPPYP00000016016 | ENSPPYP00000012976 | ACTL6A isoform 2; Belongs to the actin family. | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. | 0.997 |
ACTL6A | SMARCC2 | ENSPPYP00000016016 | ENSPPYP00000005295 | ACTL6A isoform 2; Belongs to the actin family. | SMARCC2 isoform 7. | 0.995 |
ACTL6A | SMARCD1 | ENSPPYP00000016016 | ENSPPYP00000005143 | ACTL6A isoform 2; Belongs to the actin family. | SMARCD1 isoform 1. | 0.996 |