STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CYLDUbiquitin carboxyl-terminal hydrolase CYLD; Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-alpha-induced necroptosis. Plays an important role in the regulation of pathways leading to NF-kappa-B activation. Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation. Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules. Plays a role in the regul [...] (956 aa)    
Predicted Functional Partners:
TNFRSF1A
TNFRSF1A isoform 2.
    
 0.997
RIPK1
Receptor interacting serine/threonine kinase 1.
    
 0.997
TRAF6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
    
 0.996
IKBKE
Inhibitor of nuclear factor kappa B kinase subunit epsilon.
   
 0.987
IKBKG
Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.
    
 0.986
TRAF2
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
    
 0.983
DDX58
DDX58 isoform 2.
    
 0.977
RNF31
T0114761 isoform 1.
    
 0.976
BCL3
BCL3 isoform 3.
   
 0.969
SPATA2
SPATA2 isoform 1.
     
 0.967
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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