CR201_G0015086 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APOBEC3G	CR201_G0015086	ENSPPYP00000013200	ENSPPYP00000008404	APOBEC3G isoform 1.	CBFB isoform 2.	0.823
APOBEC3G	CUL5	ENSPPYP00000013200	ENSPPYP00000004398	APOBEC3G isoform 1.	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	0.914
CBX6	CR201_G0015086	ENSPPYP00000013197	ENSPPYP00000008404	CBX6 isoform 1.	CBFB isoform 2.	0.809
CR201_G0015086	APOBEC3G	ENSPPYP00000008404	ENSPPYP00000013200	CBFB isoform 2.	APOBEC3G isoform 1.	0.823
CR201_G0015086	CBX6	ENSPPYP00000008404	ENSPPYP00000013197	CBFB isoform 2.	CBX6 isoform 1.	0.809
CR201_G0015086	CUL5	ENSPPYP00000008404	ENSPPYP00000004398	CBFB isoform 2.	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	0.954
CR201_G0015086	ENSPPYP00000011486	ENSPPYP00000008404	ENSPPYP00000011486	CBFB isoform 2.	annotation not available	0.824
CR201_G0015086	HIPK2	ENSPPYP00000008404	ENSPPYP00000020253	CBFB isoform 2.	HIPK2 isoform 2.	0.813
CR201_G0015086	LOC100458762	ENSPPYP00000008404	ENSPPYP00000013204	CBFB isoform 2.	CMP/dCMP-type deaminase domain-containing protein.	0.817
CR201_G0015086	PPM1D	ENSPPYP00000008404	ENSPPYP00000009568	CBFB isoform 2.	PPM1D isoform 2.	0.822
CR201_G0015086	RUNX1	ENSPPYP00000008404	ENSPPYP00000012719	CBFB isoform 2.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.995
CR201_G0015086	RUNX2	ENSPPYP00000008404	ENSPPYP00000018641	CBFB isoform 2.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.989
CR201_G0015086	RUNX3	ENSPPYP00000008404	ENSPPYP00000001981	CBFB isoform 2.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.990
CUL5	APOBEC3G	ENSPPYP00000004398	ENSPPYP00000013200	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	APOBEC3G isoform 1.	0.914
CUL5	CR201_G0015086	ENSPPYP00000004398	ENSPPYP00000008404	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	CBFB isoform 2.	0.954
CUL5	LOC100458762	ENSPPYP00000004398	ENSPPYP00000013204	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	CMP/dCMP-type deaminase domain-containing protein.	0.878
ENSPPYP00000011486	CR201_G0015086	ENSPPYP00000011486	ENSPPYP00000008404	annotation not available	CBFB isoform 2.	0.824
ENSPPYP00000011486	RUNX1	ENSPPYP00000011486	ENSPPYP00000012719	annotation not available	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.733
ENSPPYP00000011486	RUNX2	ENSPPYP00000011486	ENSPPYP00000018641	annotation not available	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.703
ENSPPYP00000011486	RUNX3	ENSPPYP00000011486	ENSPPYP00000001981	annotation not available	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.696