| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AGRP | CCK | ENSPPYP00000008427 | ENSPPYP00000015640 | Agouti related neuropeptide. | Cholecystokinin. | 0.740 |
| AGRP | FOXO1 | ENSPPYP00000008427 | ENSPPYP00000006042 | Agouti related neuropeptide. | FOXO1 isoform 1. | 0.739 |
| AGRP | GHRL | ENSPPYP00000008427 | ENSPPYP00000015270 | Agouti related neuropeptide. | Ghrelin and obestatin prepropeptide. | 0.801 |
| AGRP | HCRT | ENSPPYP00000008427 | ENSPPYP00000009442 | Agouti related neuropeptide. | Orexin; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Belongs to the orexin family. | 0.820 |
| AGRP | LEP | ENSPPYP00000008427 | ENSPPYP00000020162 | Agouti related neuropeptide. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.794 |
| AGRP | MC3R | ENSPPYP00000008427 | ENSPPYP00000012454 | Agouti related neuropeptide. | Melanocortin 3 receptor. | 0.974 |
| AGRP | MC4R | ENSPPYP00000008427 | ENSPPYP00000010328 | Agouti related neuropeptide. | Melanocortin 4 receptor. | 0.994 |
| AGRP | NPY | ENSPPYP00000008427 | ENSPPYP00000019866 | Agouti related neuropeptide. | NPY isoform 1. | 0.886 |
| AGRP | POMC | ENSPPYP00000008427 | ENSPPYP00000014061 | Agouti related neuropeptide. | POMC isoform 1. | 0.825 |
| AGRP | TRPV1 | ENSPPYP00000008427 | ENSPPYP00000008801 | Agouti related neuropeptide. | TRPV1 isoform 1; Belongs to the transient receptor (TC 1.A.4) family. | 0.725 |
| CCK | AGRP | ENSPPYP00000015640 | ENSPPYP00000008427 | Cholecystokinin. | Agouti related neuropeptide. | 0.740 |
| CCK | GHRL | ENSPPYP00000015640 | ENSPPYP00000015270 | Cholecystokinin. | Ghrelin and obestatin prepropeptide. | 0.751 |
| CCK | HCRT | ENSPPYP00000015640 | ENSPPYP00000009442 | Cholecystokinin. | Orexin; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Belongs to the orexin family. | 0.740 |
| CCK | LEP | ENSPPYP00000015640 | ENSPPYP00000020162 | Cholecystokinin. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.586 |
| CCK | MC4R | ENSPPYP00000015640 | ENSPPYP00000010328 | Cholecystokinin. | Melanocortin 4 receptor. | 0.632 |
| CCK | NPY | ENSPPYP00000015640 | ENSPPYP00000019866 | Cholecystokinin. | NPY isoform 1. | 0.797 |
| CCK | POMC | ENSPPYP00000015640 | ENSPPYP00000014061 | Cholecystokinin. | POMC isoform 1. | 0.729 |
| FOXO1 | AGRP | ENSPPYP00000006042 | ENSPPYP00000008427 | FOXO1 isoform 1. | Agouti related neuropeptide. | 0.739 |
| FOXO1 | LEP | ENSPPYP00000006042 | ENSPPYP00000020162 | FOXO1 isoform 1. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.485 |
| FOXO1 | POMC | ENSPPYP00000006042 | ENSPPYP00000014061 | FOXO1 isoform 1. | POMC isoform 1. | 0.671 |
