| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADK | ADSL | ENSPPYP00000002693 | ENSPPYP00000013221 | ADK isoform 4. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.972 |
| ADK | AK2 | ENSPPYP00000002693 | ENSPPYP00000001820 | ADK isoform 4. | Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. | 0.969 |
| ADK | AK8 | ENSPPYP00000002693 | ENSPPYP00000022108 | ADK isoform 4. | AK8 isoform 2; Belongs to the adenylate kinase family. | 0.965 |
| ADK | AK9 | ENSPPYP00000002693 | ENSPPYP00000018934 | ADK isoform 4. | AK9 isoform 2. | 0.938 |
| ADK | AMPD1 | ENSPPYP00000002693 | ENSPPYP00000001164 | ADK isoform 4. | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | 0.960 |
| ADK | AMPD2 | ENSPPYP00000002693 | ENSPPYP00000001238 | ADK isoform 4. | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | 0.961 |
| ADK | APRT | ENSPPYP00000002693 | ENSPPYP00000008627 | ADK isoform 4. | APRT isoform 1. | 0.986 |
| ADK | ATIC | ENSPPYP00000002693 | ENSPPYP00000014690 | ADK isoform 4. | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | 0.626 |
| ADK | MTAP | ENSPPYP00000002693 | ENSPPYP00000021480 | ADK isoform 4. | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. | 0.644 |
| ADK | PNP | ENSPPYP00000002693 | ENSPPYP00000006336 | ADK isoform 4. | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.970 |
| ADSL | ADK | ENSPPYP00000013221 | ENSPPYP00000002693 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | ADK isoform 4. | 0.972 |
| ADSL | AK2 | ENSPPYP00000013221 | ENSPPYP00000001820 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. | 0.967 |
| ADSL | AK8 | ENSPPYP00000013221 | ENSPPYP00000022108 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | AK8 isoform 2; Belongs to the adenylate kinase family. | 0.967 |
| ADSL | AK9 | ENSPPYP00000013221 | ENSPPYP00000018934 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | AK9 isoform 2. | 0.992 |
| ADSL | AMPD1 | ENSPPYP00000013221 | ENSPPYP00000001164 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | 0.936 |
| ADSL | AMPD2 | ENSPPYP00000013221 | ENSPPYP00000001238 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | 0.935 |
| ADSL | APRT | ENSPPYP00000013221 | ENSPPYP00000008627 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | APRT isoform 1. | 0.983 |
| ADSL | ATIC | ENSPPYP00000013221 | ENSPPYP00000014690 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | 0.999 |
| ADSL | PNP | ENSPPYP00000013221 | ENSPPYP00000006336 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.475 |
| AK2 | ADK | ENSPPYP00000001820 | ENSPPYP00000002693 | Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. | ADK isoform 4. | 0.969 |
