STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CRKCRK isoform 1. (204 aa)    
Predicted Functional Partners:
RAPGEF1
RAPGEF1 isoform 1.
    
 0.990
CBL
Cbl proto-oncogene.
    
 0.986
ABL1
Tyrosine-protein kinase.
    
 0.981
GAB1
GAB1 isoform 1.
    
 0.976
ELMO2
Engulfment and cell motility protein 2; Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity).
    
 0.975
PTK2
PTK2 isoform 11; Belongs to the protein kinase superfamily. Tyr protein kinase family.
    
 0.974
FRS2
Fibroblast growth factor receptor substrate 2.
   
 0.968
ELMO1
ELMO1 isoform 1.
    
 0.968
EGFR
Receptor protein-tyrosine kinase.
    
 0.967
SRC
Tyrosine-protein kinase.
   
 0.965
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.