node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADSS1 | ADSS2 | ENSPPYP00000007034 | ENSPPYP00000000054 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | 0.901 |
ADSS1 | ASNS | ENSPPYP00000007034 | ENSPPYP00000019942 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Asparagine synthetase [glutamine-hydrolyzing]. | 0.924 |
ADSS1 | ASPA | ENSPPYP00000007034 | ENSPPYP00000008799 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Aspartoacylase; Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids (By similarity). | 0.901 |
ADSS1 | ASRGL1 | ENSPPYP00000007034 | ENSPPYP00000003658 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Asparaginase and isoaspartyl peptidase 1. | 0.907 |
ADSS1 | ASS1 | ENSPPYP00000007034 | ENSPPYP00000022070 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | ASS1 isoform 1. | 0.929 |
ADSS1 | GOT2 | ENSPPYP00000007034 | ENSPPYP00000008377 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Aspartate aminotransferase, mitochondrial; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (By similarity). | 0.923 |
ADSS1 | NAT8L | ENSPPYP00000007034 | ENSPPYP00000016246 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | NAT8L isoform 1. | 0.900 |
ADSS2 | ADSS1 | ENSPPYP00000000054 | ENSPPYP00000007034 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | 0.901 |
ADSS2 | ASNS | ENSPPYP00000000054 | ENSPPYP00000019942 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Asparagine synthetase [glutamine-hydrolyzing]. | 0.924 |
ADSS2 | ASPA | ENSPPYP00000000054 | ENSPPYP00000008799 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Aspartoacylase; Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids (By similarity). | 0.901 |
ADSS2 | ASRGL1 | ENSPPYP00000000054 | ENSPPYP00000003658 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Asparaginase and isoaspartyl peptidase 1. | 0.908 |
ADSS2 | ASS1 | ENSPPYP00000000054 | ENSPPYP00000022070 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | ASS1 isoform 1. | 0.929 |
ADSS2 | GOT2 | ENSPPYP00000000054 | ENSPPYP00000008377 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Aspartate aminotransferase, mitochondrial; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (By similarity). | 0.923 |
ADSS2 | NAT8L | ENSPPYP00000000054 | ENSPPYP00000016246 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | NAT8L isoform 1. | 0.900 |
ASNS | ADSS1 | ENSPPYP00000019942 | ENSPPYP00000007034 | Asparagine synthetase [glutamine-hydrolyzing]. | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | 0.924 |
ASNS | ADSS2 | ENSPPYP00000019942 | ENSPPYP00000000054 | Asparagine synthetase [glutamine-hydrolyzing]. | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | 0.924 |
ASNS | ASPA | ENSPPYP00000019942 | ENSPPYP00000008799 | Asparagine synthetase [glutamine-hydrolyzing]. | Aspartoacylase; Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids (By similarity). | 0.901 |
ASNS | ASRGL1 | ENSPPYP00000019942 | ENSPPYP00000003658 | Asparagine synthetase [glutamine-hydrolyzing]. | Asparaginase and isoaspartyl peptidase 1. | 0.946 |
ASNS | ASS1 | ENSPPYP00000019942 | ENSPPYP00000022070 | Asparagine synthetase [glutamine-hydrolyzing]. | ASS1 isoform 1. | 0.922 |
ASNS | GOT2 | ENSPPYP00000019942 | ENSPPYP00000008377 | Asparagine synthetase [glutamine-hydrolyzing]. | Aspartate aminotransferase, mitochondrial; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (By similarity). | 0.944 |