STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MIS12Protein MIS12 homolog; Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis. Essential for proper kinetochore microtubule attachments. (205 aa)    
Predicted Functional Partners:
DSN1
DSN1 isoform 1.
    
 0.999
NSL1
NSL1 component of MIS12 kinetochore complex.
    
 0.996
PMF1
Polyamine-modulated factor 1 isoform X1.
    
 0.992
NDC80
NDC80 kinetochore complex component.
   
 0.978
SPC24
SPC24 isoform 3.
   
 0.977
NUF2
NUF2 component of NDC80 kinetochore complex.
   
 0.971
ZWINT
ZW10 interacting kinetochore protein.
    
 
 0.945
SPC25
SPC25 isoform 2.
    
 0.943
BUB1
BUB1 mitotic checkpoint serine/threonine kinase.
    
 0.938
BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta.
    
 0.928
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.