STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DVL2DVL2 isoform 1. (677 aa)    
Predicted Functional Partners:
FZD4
FZD4 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family.
   
 0.996
DVL3
DVL3 isoform 1.
  
 
0.988
VANGL2
Vang-like protein.
    
 0.984
VANGL1
Vang-like protein.
    
 0.984
FZD5
Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.982
FZD6
Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...]
    
 0.981
FZD7
Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.980
FZD1
Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.980
FZD2
Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.979
CR201_G0054585
AXIN1 isoform 6.
   
 0.977
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.