| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CLOCK | CRY1 | ENSPPYP00000016487 | ENSPPYP00000005604 | Circadian locomoter output cycles protein kaput; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, [...] | Cryptochrome circadian regulator 1. | 0.996 |
| CLOCK | CRY2 | ENSPPYP00000016487 | ENSPPYP00000003822 | Circadian locomoter output cycles protein kaput; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, [...] | Cryptochrome circadian regulator 2. | 0.996 |
| CLOCK | CSNK1D | ENSPPYP00000016487 | ENSPPYP00000009846 | Circadian locomoter output cycles protein kaput; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, [...] | Casein kinase I isoform delta; Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, dete [...] | 0.975 |
| CLOCK | LOC100447547 | ENSPPYP00000016487 | ENSPPYP00000013183 | Circadian locomoter output cycles protein kaput; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, [...] | T0085674 isoform 1; Belongs to the protein kinase superfamily. | 0.976 |
| CLOCK | NPAS2 | ENSPPYP00000016487 | ENSPPYP00000013492 | Circadian locomoter output cycles protein kaput; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, [...] | NPAS2 isoform 1. | 0.992 |
| CLOCK | PER1 | ENSPPYP00000016487 | ENSPPYP00000008937 | Circadian locomoter output cycles protein kaput; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, [...] | PER1 isoform 10. | 0.756 |
| CLOCK | PER2 | ENSPPYP00000016487 | ENSPPYP00000014901 | Circadian locomoter output cycles protein kaput; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, [...] | PER2 isoform 2. | 0.986 |
| CLOCK | PER3 | ENSPPYP00000016487 | ENSPPYP00000002238 | Circadian locomoter output cycles protein kaput; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, [...] | PER3 isoform 5. | 0.785 |
| CLOCK | TIMELESS | ENSPPYP00000016487 | ENSPPYP00000005311 | Circadian locomoter output cycles protein kaput; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, [...] | TIMELESS isoform 2. | 0.757 |
| CRY1 | CLOCK | ENSPPYP00000005604 | ENSPPYP00000016487 | Cryptochrome circadian regulator 1. | Circadian locomoter output cycles protein kaput; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, [...] | 0.996 |
| CRY1 | CRY2 | ENSPPYP00000005604 | ENSPPYP00000003822 | Cryptochrome circadian regulator 1. | Cryptochrome circadian regulator 2. | 0.993 |
| CRY1 | CSNK1D | ENSPPYP00000005604 | ENSPPYP00000009846 | Cryptochrome circadian regulator 1. | Casein kinase I isoform delta; Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, dete [...] | 0.983 |
| CRY1 | LOC100447547 | ENSPPYP00000005604 | ENSPPYP00000013183 | Cryptochrome circadian regulator 1. | T0085674 isoform 1; Belongs to the protein kinase superfamily. | 0.991 |
| CRY1 | NPAS2 | ENSPPYP00000005604 | ENSPPYP00000013492 | Cryptochrome circadian regulator 1. | NPAS2 isoform 1. | 0.994 |
| CRY1 | PER1 | ENSPPYP00000005604 | ENSPPYP00000008937 | Cryptochrome circadian regulator 1. | PER1 isoform 10. | 0.951 |
| CRY1 | PER2 | ENSPPYP00000005604 | ENSPPYP00000014901 | Cryptochrome circadian regulator 1. | PER2 isoform 2. | 0.999 |
| CRY1 | PER3 | ENSPPYP00000005604 | ENSPPYP00000002238 | Cryptochrome circadian regulator 1. | PER3 isoform 5. | 0.988 |
| CRY1 | TIMELESS | ENSPPYP00000005604 | ENSPPYP00000005311 | Cryptochrome circadian regulator 1. | TIMELESS isoform 2. | 0.934 |
| CRY2 | CLOCK | ENSPPYP00000003822 | ENSPPYP00000016487 | Cryptochrome circadian regulator 2. | Circadian locomoter output cycles protein kaput; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, [...] | 0.996 |
| CRY2 | CRY1 | ENSPPYP00000003822 | ENSPPYP00000005604 | Cryptochrome circadian regulator 2. | Cryptochrome circadian regulator 1. | 0.993 |