| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DHFR2 | GART | ENSPPYP00000015237 | ENSPPYP00000012701 | Dihydrofolate reductase 2; Belongs to the dihydrofolate reductase family. | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. | 0.963 |
| DHFR2 | GCSH | ENSPPYP00000015237 | ENSPPYP00000008560 | Dihydrofolate reductase 2; Belongs to the dihydrofolate reductase family. | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | 0.675 |
| DHFR2 | GLDC | ENSPPYP00000015237 | ENSPPYP00000021533 | Dihydrofolate reductase 2; Belongs to the dihydrofolate reductase family. | Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.719 |
| DHFR2 | MTHFD1 | ENSPPYP00000015237 | ENSPPYP00000006705 | Dihydrofolate reductase 2; Belongs to the dihydrofolate reductase family. | C-1-tetrahydrofolate synthase, cytoplasmic; In the C-terminal section; belongs to the formate-- tetrahydrofolate ligase family. | 0.955 |
| DHFR2 | MTHFD1L | ENSPPYP00000015237 | ENSPPYP00000019152 | Dihydrofolate reductase 2; Belongs to the dihydrofolate reductase family. | MTHFD1L isoform 1. | 0.951 |
| DHFR2 | MTHFR | ENSPPYP00000015237 | ENSPPYP00000002178 | Dihydrofolate reductase 2; Belongs to the dihydrofolate reductase family. | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.480 |
| DHFR2 | SARDH | ENSPPYP00000015237 | ENSPPYP00000022141 | Dihydrofolate reductase 2; Belongs to the dihydrofolate reductase family. | SARDH isoform 2. | 0.983 |
| DHFR2 | SHMT1 | ENSPPYP00000015237 | ENSPPYP00000009057 | Dihydrofolate reductase 2; Belongs to the dihydrofolate reductase family. | Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. | 0.985 |
| DHFR2 | SHMT2 | ENSPPYP00000015237 | ENSPPYP00000005336 | Dihydrofolate reductase 2; Belongs to the dihydrofolate reductase family. | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.969 |
| DHFR2 | TYMS | ENSPPYP00000015237 | ENSPPYP00000010155 | Dihydrofolate reductase 2; Belongs to the dihydrofolate reductase family. | Thymidylate synthetase. | 0.998 |
| GART | DHFR2 | ENSPPYP00000012701 | ENSPPYP00000015237 | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. | Dihydrofolate reductase 2; Belongs to the dihydrofolate reductase family. | 0.963 |
| GART | GCSH | ENSPPYP00000012701 | ENSPPYP00000008560 | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | 0.823 |
| GART | GLDC | ENSPPYP00000012701 | ENSPPYP00000021533 | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. | Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.941 |
| GART | MTHFD1 | ENSPPYP00000012701 | ENSPPYP00000006705 | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. | C-1-tetrahydrofolate synthase, cytoplasmic; In the C-terminal section; belongs to the formate-- tetrahydrofolate ligase family. | 0.999 |
| GART | MTHFD1L | ENSPPYP00000012701 | ENSPPYP00000019152 | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. | MTHFD1L isoform 1. | 0.999 |
| GART | MTHFR | ENSPPYP00000012701 | ENSPPYP00000002178 | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.772 |
| GART | SARDH | ENSPPYP00000012701 | ENSPPYP00000022141 | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. | SARDH isoform 2. | 0.955 |
| GART | SHMT1 | ENSPPYP00000012701 | ENSPPYP00000009057 | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. | Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. | 0.997 |
| GART | SHMT2 | ENSPPYP00000012701 | ENSPPYP00000005336 | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.997 |
| GART | TYMS | ENSPPYP00000012701 | ENSPPYP00000010155 | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. | Thymidylate synthetase. | 0.713 |
