| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CLNS1A | COPRS | ENSPPYP00000004240 | ENSPPYP00000009165 | Methylosome subunit pICln; Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins. Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity). Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cyto [...] | Coordinator of PRMT5 and differentiation stimulator. | 0.820 |
| CLNS1A | LSM4 | ENSPPYP00000004240 | ENSPPYP00000010908 | Methylosome subunit pICln; Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins. Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity). Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cyto [...] | U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. | 0.623 |
| CLNS1A | PRMT5 | ENSPPYP00000004240 | ENSPPYP00000006422 | Methylosome subunit pICln; Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins. Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity). Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cyto [...] | Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H and may regulate its transcriptional elongation properties (By similarity). Mono- and dimethylates arginine resi [...] | 0.999 |
| CLNS1A | RIOK1 | ENSPPYP00000004240 | ENSPPYP00000018128 | Methylosome subunit pICln; Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins. Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity). Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cyto [...] | Serine/threonine-protein kinase RIO1; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. | 0.600 |
| CLNS1A | WDR77 | ENSPPYP00000004240 | ENSPPYP00000001202 | Methylosome subunit pICln; Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins. Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity). Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cyto [...] | Methylosome protein 50; Non-catalytic component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The methylosome complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-contain [...] | 0.999 |
| COPRS | CLNS1A | ENSPPYP00000009165 | ENSPPYP00000004240 | Coordinator of PRMT5 and differentiation stimulator. | Methylosome subunit pICln; Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins. Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity). Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cyto [...] | 0.820 |
| COPRS | CRLF3 | ENSPPYP00000009165 | ENSPPYP00000009152 | Coordinator of PRMT5 and differentiation stimulator. | Cytokine receptor like factor 3. | 0.773 |
| COPRS | DUS2 | ENSPPYP00000009165 | ENSPPYP00000008450 | Coordinator of PRMT5 and differentiation stimulator. | Dihydrouridine synthase 2. | 0.726 |
| COPRS | EVI2B | ENSPPYP00000009165 | ENSPPYP00000009161 | Coordinator of PRMT5 and differentiation stimulator. | EVI2B isoform 1. | 0.735 |
| COPRS | LSM4 | ENSPPYP00000009165 | ENSPPYP00000010908 | Coordinator of PRMT5 and differentiation stimulator. | U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. | 0.731 |
| COPRS | OMG | ENSPPYP00000009165 | ENSPPYP00000009160 | Coordinator of PRMT5 and differentiation stimulator. | OMG isoform 2. | 0.767 |
| COPRS | PRMT5 | ENSPPYP00000009165 | ENSPPYP00000006422 | Coordinator of PRMT5 and differentiation stimulator. | Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H and may regulate its transcriptional elongation properties (By similarity). Mono- and dimethylates arginine resi [...] | 0.966 |
| COPRS | RIOK1 | ENSPPYP00000009165 | ENSPPYP00000018128 | Coordinator of PRMT5 and differentiation stimulator. | Serine/threonine-protein kinase RIO1; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. | 0.955 |
| COPRS | TEFM | ENSPPYP00000009165 | ENSPPYP00000009154 | Coordinator of PRMT5 and differentiation stimulator. | Transcription elongation factor, mitochondrial. | 0.722 |
| COPRS | WDR77 | ENSPPYP00000009165 | ENSPPYP00000001202 | Coordinator of PRMT5 and differentiation stimulator. | Methylosome protein 50; Non-catalytic component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The methylosome complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-contain [...] | 0.947 |
| CRLF3 | COPRS | ENSPPYP00000009152 | ENSPPYP00000009165 | Cytokine receptor like factor 3. | Coordinator of PRMT5 and differentiation stimulator. | 0.773 |
| CRLF3 | EVI2B | ENSPPYP00000009152 | ENSPPYP00000009161 | Cytokine receptor like factor 3. | EVI2B isoform 1. | 0.621 |
| CRLF3 | OMG | ENSPPYP00000009152 | ENSPPYP00000009160 | Cytokine receptor like factor 3. | OMG isoform 2. | 0.756 |
| CRLF3 | TEFM | ENSPPYP00000009152 | ENSPPYP00000009154 | Cytokine receptor like factor 3. | Transcription elongation factor, mitochondrial. | 0.717 |
| DUS2 | COPRS | ENSPPYP00000008450 | ENSPPYP00000009165 | Dihydrouridine synthase 2. | Coordinator of PRMT5 and differentiation stimulator. | 0.726 |
