STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMG8Protein SMG8. (987 aa)    
Predicted Functional Partners:
SMG1
SMG1 isoform 8; Belongs to the PI3/PI4-kinase family.
   
 0.995
SMG9
SMG9 nonsense mediated mRNA decay factor.
    
 0.995
CR201_G0047047
SMG1 isoform 2.
   
 0.892
SMG5
SMG5 nonsense mediated mRNA decay factor.
     
 0.763
SMG6
Telomerase-binding protein EST1A; Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. May have a general role in telomere regulation. Promotes in vitro the ability of TERT to elongate telomeres. Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization. Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER).
     
 0.754
PRKDC
PRKDC isoform 1; Belongs to the PI3/PI4-kinase family.
   
 0.740
SMG7
SMG7 nonsense mediated mRNA decay factor.
     
 0.730
DCP1A
DCP1A isoform 1.
   
 
 0.726
UPF1
UPF1 isoform 2.
    
 
 0.699
UPF2
UPF2 isoform 1.
   
  
 0.688
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.