| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AQR | CACTIN | ENSPPYP00000007160 | ENSPPYP00000010523 | RNA helicase aquarius; Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre- mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing. | CACTIN isoform 1. | 0.583 |
| AQR | CCDC12 | ENSPPYP00000007160 | ENSPPYP00000015576 | RNA helicase aquarius; Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre- mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing. | Coiled-coil domain containing 12. | 0.830 |
| AQR | CDC40 | ENSPPYP00000007160 | ENSPPYP00000018941 | RNA helicase aquarius; Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre- mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing. | CDC40 isoform 1. | 0.913 |
| AQR | CRNKL1 | ENSPPYP00000007160 | ENSPPYP00000012012 | RNA helicase aquarius; Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre- mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing. | Crooked neck pre-mRNA splicing factor 1. | 0.997 |
| AQR | CWC22 | ENSPPYP00000007160 | ENSPPYP00000014506 | RNA helicase aquarius; Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre- mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing. | Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing as component of the spliceosome. Promotes exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay. | 0.948 |
| AQR | DHX8 | ENSPPYP00000007160 | ENSPPYP00000009394 | RNA helicase aquarius; Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre- mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing. | DEAH-box helicase 8. | 0.961 |
| AQR | PPIL1 | ENSPPYP00000007160 | ENSPPYP00000018515 | RNA helicase aquarius; Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre- mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing. | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. | 0.903 |
| AQR | SLU7 | ENSPPYP00000007160 | ENSPPYP00000017914 | RNA helicase aquarius; Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre- mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing. | SLU7 homolog, splicing factor. | 0.802 |
| AQR | SYF2 | ENSPPYP00000007160 | ENSPPYP00000001980 | RNA helicase aquarius; Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre- mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing. | SYF2 pre-mRNA splicing factor. | 0.954 |
| CACTIN | AQR | ENSPPYP00000010523 | ENSPPYP00000007160 | CACTIN isoform 1. | RNA helicase aquarius; Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre- mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing. | 0.583 |
| CACTIN | CCDC12 | ENSPPYP00000010523 | ENSPPYP00000015576 | CACTIN isoform 1. | Coiled-coil domain containing 12. | 0.953 |
| CACTIN | CDC40 | ENSPPYP00000010523 | ENSPPYP00000018941 | CACTIN isoform 1. | CDC40 isoform 1. | 0.964 |
| CACTIN | CRNKL1 | ENSPPYP00000010523 | ENSPPYP00000012012 | CACTIN isoform 1. | Crooked neck pre-mRNA splicing factor 1. | 0.838 |
| CACTIN | CWC22 | ENSPPYP00000010523 | ENSPPYP00000014506 | CACTIN isoform 1. | Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing as component of the spliceosome. Promotes exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay. | 0.962 |
| CACTIN | DHX8 | ENSPPYP00000010523 | ENSPPYP00000009394 | CACTIN isoform 1. | DEAH-box helicase 8. | 0.961 |
| CACTIN | PPIL1 | ENSPPYP00000010523 | ENSPPYP00000018515 | CACTIN isoform 1. | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. | 0.958 |
| CACTIN | PRPF18 | ENSPPYP00000010523 | ENSPPYP00000002439 | CACTIN isoform 1. | Pre-mRNA-splicing factor 18; Participates in the second step of pre-mRNA splicing. | 0.855 |
| CACTIN | SLU7 | ENSPPYP00000010523 | ENSPPYP00000017914 | CACTIN isoform 1. | SLU7 homolog, splicing factor. | 0.974 |
| CACTIN | SYF2 | ENSPPYP00000010523 | ENSPPYP00000001980 | CACTIN isoform 1. | SYF2 pre-mRNA splicing factor. | 0.931 |
| CCDC12 | AQR | ENSPPYP00000015576 | ENSPPYP00000007160 | Coiled-coil domain containing 12. | RNA helicase aquarius; Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre- mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing. | 0.830 |
