STAT3 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EGFR	JAK1	ENSPPYP00000019671	ENSPPYP00000001481	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase.	0.962
EGFR	JAK2	ENSPPYP00000019671	ENSPPYP00000021551	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...]	0.983
EGFR	JAK3	ENSPPYP00000019671	ENSPPYP00000010896	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase.	0.944
EGFR	PTPN2	ENSPPYP00000019671	ENSPPYP00000010078	Receptor protein-tyrosine kinase.	Tyrosine-protein phosphatase non-receptor type.	0.664
EGFR	SRC	ENSPPYP00000019671	ENSPPYP00000012270	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase.	0.997
EGFR	STAT1	ENSPPYP00000019671	ENSPPYP00000014555	Receptor protein-tyrosine kinase.	Signal transducer and activator of transcription.	0.996
EGFR	STAT3	ENSPPYP00000019671	ENSPPYP00000009437	Receptor protein-tyrosine kinase.	Signal transducer and activator of transcription.	0.997
EGFR	STAT4	ENSPPYP00000019671	ENSPPYP00000014556	Receptor protein-tyrosine kinase.	Signal transducer and activator of transcription.	0.631
EP300	STAT1	ENSPPYP00000013236	ENSPPYP00000014555	EP300 isoform 1.	Signal transducer and activator of transcription.	0.996
EP300	STAT3	ENSPPYP00000013236	ENSPPYP00000009437	EP300 isoform 1.	Signal transducer and activator of transcription.	0.998
EP300	STAT4	ENSPPYP00000013236	ENSPPYP00000014556	EP300 isoform 1.	Signal transducer and activator of transcription.	0.980
JAK1	EGFR	ENSPPYP00000001481	ENSPPYP00000019671	Tyrosine-protein kinase.	Receptor protein-tyrosine kinase.	0.962
JAK1	JAK2	ENSPPYP00000001481	ENSPPYP00000021551	Tyrosine-protein kinase.	Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...]	0.996
JAK1	JAK3	ENSPPYP00000001481	ENSPPYP00000010896	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.996
JAK1	PTPN2	ENSPPYP00000001481	ENSPPYP00000010078	Tyrosine-protein kinase.	Tyrosine-protein phosphatase non-receptor type.	0.974
JAK1	STAT1	ENSPPYP00000001481	ENSPPYP00000014555	Tyrosine-protein kinase.	Signal transducer and activator of transcription.	0.999
JAK1	STAT3	ENSPPYP00000001481	ENSPPYP00000009437	Tyrosine-protein kinase.	Signal transducer and activator of transcription.	0.997
JAK1	STAT4	ENSPPYP00000001481	ENSPPYP00000014556	Tyrosine-protein kinase.	Signal transducer and activator of transcription.	0.986
JAK2	EGFR	ENSPPYP00000021551	ENSPPYP00000019671	Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...]	Receptor protein-tyrosine kinase.	0.983
JAK2	JAK1	ENSPPYP00000021551	ENSPPYP00000001481	Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...]	Tyrosine-protein kinase.	0.996