| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCNA1 | CCNA2 | ENSPPYP00000006017 | ENSPPYP00000016798 | CCNA1 isoform 3; Belongs to the cyclin family. | CCNA2 isoform 1; Belongs to the cyclin family. | 0.994 |
| CCNA1 | CDC6 | ENSPPYP00000006017 | ENSPPYP00000009512 | CCNA1 isoform 3; Belongs to the cyclin family. | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | 0.996 |
| CCNA1 | CDK2 | ENSPPYP00000006017 | ENSPPYP00000005283 | CCNA1 isoform 3; Belongs to the cyclin family. | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. | 0.999 |
| CCNA1 | CR201_G0048355 | ENSPPYP00000006017 | ENSPPYP00000008626 | CCNA1 isoform 3; Belongs to the cyclin family. | CDT1 isoform 1. | 0.958 |
| CCNA1 | MCM10 | ENSPPYP00000006017 | ENSPPYP00000002433 | CCNA1 isoform 3; Belongs to the cyclin family. | MCM10 isoform 1. | 0.676 |
| CCNA1 | MCM3 | ENSPPYP00000006017 | ENSPPYP00000018688 | CCNA1 isoform 3; Belongs to the cyclin family. | DNA replication licensing factor MCM3; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.783 |
| CCNA1 | MCM7 | ENSPPYP00000006017 | ENSPPYP00000019497 | CCNA1 isoform 3; Belongs to the cyclin family. | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.851 |
| CCNA1 | ORC1 | ENSPPYP00000006017 | ENSPPYP00000001568 | CCNA1 isoform 3; Belongs to the cyclin family. | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. | 0.931 |
| CCNA1 | ORC3 | ENSPPYP00000006017 | ENSPPYP00000018843 | CCNA1 isoform 3; Belongs to the cyclin family. | Origin recognition complex subunit 3. | 0.651 |
| CCNA1 | ORC6 | ENSPPYP00000006017 | ENSPPYP00000008716 | CCNA1 isoform 3; Belongs to the cyclin family. | ORC6 isoform 2. | 0.640 |
| CCNA2 | CCNA1 | ENSPPYP00000016798 | ENSPPYP00000006017 | CCNA2 isoform 1; Belongs to the cyclin family. | CCNA1 isoform 3; Belongs to the cyclin family. | 0.994 |
| CCNA2 | CDC6 | ENSPPYP00000016798 | ENSPPYP00000009512 | CCNA2 isoform 1; Belongs to the cyclin family. | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | 0.998 |
| CCNA2 | CDK2 | ENSPPYP00000016798 | ENSPPYP00000005283 | CCNA2 isoform 1; Belongs to the cyclin family. | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. | 0.999 |
| CCNA2 | CR201_G0048355 | ENSPPYP00000016798 | ENSPPYP00000008626 | CCNA2 isoform 1; Belongs to the cyclin family. | CDT1 isoform 1. | 0.983 |
| CCNA2 | MCM10 | ENSPPYP00000016798 | ENSPPYP00000002433 | CCNA2 isoform 1; Belongs to the cyclin family. | MCM10 isoform 1. | 0.731 |
| CCNA2 | MCM3 | ENSPPYP00000016798 | ENSPPYP00000018688 | CCNA2 isoform 1; Belongs to the cyclin family. | DNA replication licensing factor MCM3; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.805 |
| CCNA2 | MCM7 | ENSPPYP00000016798 | ENSPPYP00000019497 | CCNA2 isoform 1; Belongs to the cyclin family. | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.856 |
| CCNA2 | ORC1 | ENSPPYP00000016798 | ENSPPYP00000001568 | CCNA2 isoform 1; Belongs to the cyclin family. | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. | 0.963 |
| CCNA2 | ORC3 | ENSPPYP00000016798 | ENSPPYP00000018843 | CCNA2 isoform 1; Belongs to the cyclin family. | Origin recognition complex subunit 3. | 0.578 |
| CCNA2 | ORC6 | ENSPPYP00000016798 | ENSPPYP00000008716 | CCNA2 isoform 1; Belongs to the cyclin family. | ORC6 isoform 2. | 0.631 |
