| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| PTCH1 | PTCH2 | ENSPPYP00000021750 | ENSPPYP00000001647 | PTCH1 isoform 7. | PTCH2 isoform 1. | 0.910 |
| PTCH1 | SMURF1 | ENSPPYP00000021750 | ENSPPYP00000019458 | PTCH1 isoform 7. | E3 ubiquitin-protein ligase. | 0.985 |
| PTCH1 | SMURF2 | ENSPPYP00000021750 | ENSPPYP00000009604 | PTCH1 isoform 7. | E3 ubiquitin-protein ligase. | 0.985 |
| PTCH2 | PTCH1 | ENSPPYP00000001647 | ENSPPYP00000021750 | PTCH2 isoform 1. | PTCH1 isoform 7. | 0.910 |
| PTCH2 | SMURF1 | ENSPPYP00000001647 | ENSPPYP00000019458 | PTCH2 isoform 1. | E3 ubiquitin-protein ligase. | 0.967 |
| PTCH2 | SMURF2 | ENSPPYP00000001647 | ENSPPYP00000009604 | PTCH2 isoform 1. | E3 ubiquitin-protein ligase. | 0.967 |
| SMAD2 | SMAD3 | ENSPPYP00000010275 | ENSPPYP00000007465 | Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] | Mothers against decapentaplegic homolog. | 0.999 |
| SMAD2 | SMAD6 | ENSPPYP00000010275 | ENSPPYP00000007463 | Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] | Mothers against decapentaplegic homolog. | 0.969 |
| SMAD2 | SMAD7 | ENSPPYP00000010275 | ENSPPYP00000010278 | Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] | Mothers against decapentaplegic homolog. | 0.991 |
| SMAD2 | SMURF1 | ENSPPYP00000010275 | ENSPPYP00000019458 | Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] | E3 ubiquitin-protein ligase. | 0.892 |
| SMAD2 | SMURF2 | ENSPPYP00000010275 | ENSPPYP00000009604 | Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] | E3 ubiquitin-protein ligase. | 0.992 |
| SMAD2 | TGFBR1 | ENSPPYP00000010275 | ENSPPYP00000021783 | Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. | 0.998 |
| SMAD2 | TGFBR2 | ENSPPYP00000010275 | ENSPPYP00000015718 | Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] | 0.988 |
| SMAD2 | UBC | ENSPPYP00000010275 | ENSPPYP00000005811 | Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] | UBC isoform 2. | 0.458 |
| SMAD3 | SMAD2 | ENSPPYP00000007465 | ENSPPYP00000010275 | Mothers against decapentaplegic homolog. | Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] | 0.999 |
| SMAD3 | SMAD6 | ENSPPYP00000007465 | ENSPPYP00000007463 | Mothers against decapentaplegic homolog. | Mothers against decapentaplegic homolog. | 0.966 |
| SMAD3 | SMAD7 | ENSPPYP00000007465 | ENSPPYP00000010278 | Mothers against decapentaplegic homolog. | Mothers against decapentaplegic homolog. | 0.990 |
| SMAD3 | SMURF1 | ENSPPYP00000007465 | ENSPPYP00000019458 | Mothers against decapentaplegic homolog. | E3 ubiquitin-protein ligase. | 0.937 |
| SMAD3 | SMURF2 | ENSPPYP00000007465 | ENSPPYP00000009604 | Mothers against decapentaplegic homolog. | E3 ubiquitin-protein ligase. | 0.990 |
| SMAD3 | TGFBR1 | ENSPPYP00000007465 | ENSPPYP00000021783 | Mothers against decapentaplegic homolog. | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. | 0.996 |
