GRB2 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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structured XML interaction data, according to the 'PSI-MI' data standard

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... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EGFR	ERBB3	ENSPPYP00000019671	ENSPPYP00000005288	Receptor protein-tyrosine kinase.	Receptor tyrosine-protein kinase erbB-3; Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation.	0.992
EGFR	FRS2	ENSPPYP00000019671	ENSPPYP00000005421	Receptor protein-tyrosine kinase.	Fibroblast growth factor receptor substrate 2.	0.511
EGFR	GAB1	ENSPPYP00000019671	ENSPPYP00000016856	Receptor protein-tyrosine kinase.	GAB1 isoform 1.	0.996
EGFR	GRB2	ENSPPYP00000019671	ENSPPYP00000009686	Receptor protein-tyrosine kinase.	Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family.	0.999
EGFR	LCP2	ENSPPYP00000019671	ENSPPYP00000017943	Receptor protein-tyrosine kinase.	LCP2 isoform 3.	0.771
EGFR	PTK2	ENSPPYP00000019671	ENSPPYP00000021213	Receptor protein-tyrosine kinase.	PTK2 isoform 11; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.994
EGFR	PTPN11	ENSPPYP00000019671	ENSPPYP00000005677	Receptor protein-tyrosine kinase.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.997
EGFR	SHC1	ENSPPYP00000019671	ENSPPYP00000000893	Receptor protein-tyrosine kinase.	SHC-transforming protein 1; Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis (By similarity).	0.996
EGFR	SOS1	ENSPPYP00000019671	ENSPPYP00000013933	Receptor protein-tyrosine kinase.	SOS1 isoform 2.	0.996
EGFR	SOS2	ENSPPYP00000019671	ENSPPYP00000006588	Receptor protein-tyrosine kinase.	SOS Ras/Rho guanine nucleotide exchange factor 2.	0.995
ERBB3	EGFR	ENSPPYP00000005288	ENSPPYP00000019671	Receptor tyrosine-protein kinase erbB-3; Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation.	Receptor protein-tyrosine kinase.	0.992
ERBB3	GAB1	ENSPPYP00000005288	ENSPPYP00000016856	Receptor tyrosine-protein kinase erbB-3; Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation.	GAB1 isoform 1.	0.973
ERBB3	GRB2	ENSPPYP00000005288	ENSPPYP00000009686	Receptor tyrosine-protein kinase erbB-3; Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation.	Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family.	0.997
ERBB3	PTK2	ENSPPYP00000005288	ENSPPYP00000021213	Receptor tyrosine-protein kinase erbB-3; Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation.	PTK2 isoform 11; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.502
ERBB3	PTPN11	ENSPPYP00000005288	ENSPPYP00000005677	Receptor tyrosine-protein kinase erbB-3; Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.874
ERBB3	SHC1	ENSPPYP00000005288	ENSPPYP00000000893	Receptor tyrosine-protein kinase erbB-3; Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation.	SHC-transforming protein 1; Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis (By similarity).	0.995
ERBB3	SOS1	ENSPPYP00000005288	ENSPPYP00000013933	Receptor tyrosine-protein kinase erbB-3; Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation.	SOS1 isoform 2.	0.721
ERBB3	SOS2	ENSPPYP00000005288	ENSPPYP00000006588	Receptor tyrosine-protein kinase erbB-3; Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation.	SOS Ras/Rho guanine nucleotide exchange factor 2.	0.683
FRS2	EGFR	ENSPPYP00000005421	ENSPPYP00000019671	Fibroblast growth factor receptor substrate 2.	Receptor protein-tyrosine kinase.	0.511
FRS2	GAB1	ENSPPYP00000005421	ENSPPYP00000016856	Fibroblast growth factor receptor substrate 2.	GAB1 isoform 1.	0.810