| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AURKA | AURKB | ENSPPYP00000012456 | ENSPPYP00000008941 | AURKA isoform 10; Belongs to the protein kinase superfamily. | AURKB isoform 2; Belongs to the protein kinase superfamily. | 0.952 |
| AURKA | BIRC5 | ENSPPYP00000012456 | ENSPPYP00000009754 | AURKA isoform 10; Belongs to the protein kinase superfamily. | Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...] | 0.983 |
| AURKA | CDCA8 | ENSPPYP00000012456 | ENSPPYP00000001762 | AURKA isoform 10; Belongs to the protein kinase superfamily. | Borealin; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA (By similarity). Belongs to the borealin family. | 0.956 |
| AURKA | CDK1 | ENSPPYP00000012456 | ENSPPYP00000002808 | AURKA isoform 10; Belongs to the protein kinase superfamily. | Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, G [...] | 0.968 |
| AURKA | CR201_G0041580 | ENSPPYP00000012456 | ENSPPYP00000003662 | AURKA isoform 10; Belongs to the protein kinase superfamily. | INCENP isoform 2. | 0.963 |
| AURKA | PLK1 | ENSPPYP00000012456 | ENSPPYP00000008136 | AURKA isoform 10; Belongs to the protein kinase superfamily. | Serine/threonine-protein kinase PLK. | 0.994 |
| AURKA | XIAP | ENSPPYP00000012456 | ENSPPYP00000023167 | AURKA isoform 10; Belongs to the protein kinase superfamily. | XIAP isoform 2. | 0.654 |
| AURKB | AURKA | ENSPPYP00000008941 | ENSPPYP00000012456 | AURKB isoform 2; Belongs to the protein kinase superfamily. | AURKA isoform 10; Belongs to the protein kinase superfamily. | 0.952 |
| AURKB | BIRC5 | ENSPPYP00000008941 | ENSPPYP00000009754 | AURKB isoform 2; Belongs to the protein kinase superfamily. | Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...] | 0.995 |
| AURKB | CDCA8 | ENSPPYP00000008941 | ENSPPYP00000001762 | AURKB isoform 2; Belongs to the protein kinase superfamily. | Borealin; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA (By similarity). Belongs to the borealin family. | 0.997 |
| AURKB | CDK1 | ENSPPYP00000008941 | ENSPPYP00000002808 | AURKB isoform 2; Belongs to the protein kinase superfamily. | Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, G [...] | 0.956 |
| AURKB | CR201_G0041580 | ENSPPYP00000008941 | ENSPPYP00000003662 | AURKB isoform 2; Belongs to the protein kinase superfamily. | INCENP isoform 2. | 0.997 |
| AURKB | PLK1 | ENSPPYP00000008941 | ENSPPYP00000008136 | AURKB isoform 2; Belongs to the protein kinase superfamily. | Serine/threonine-protein kinase PLK. | 0.865 |
| AURKB | XIAP | ENSPPYP00000008941 | ENSPPYP00000023167 | AURKB isoform 2; Belongs to the protein kinase superfamily. | XIAP isoform 2. | 0.654 |
| BIRC5 | AURKA | ENSPPYP00000009754 | ENSPPYP00000012456 | Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...] | AURKA isoform 10; Belongs to the protein kinase superfamily. | 0.983 |
| BIRC5 | AURKB | ENSPPYP00000009754 | ENSPPYP00000008941 | Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...] | AURKB isoform 2; Belongs to the protein kinase superfamily. | 0.995 |
| BIRC5 | CASP3 | ENSPPYP00000009754 | ENSPPYP00000017020 | Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...] | CASP3 isoform 1; Belongs to the peptidase C14A family. | 0.985 |
| BIRC5 | CASP9 | ENSPPYP00000009754 | ENSPPYP00000002138 | Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...] | CASP9 isoform 2; Belongs to the peptidase C14A family. | 0.990 |
| BIRC5 | CDCA8 | ENSPPYP00000009754 | ENSPPYP00000001762 | Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...] | Borealin; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA (By similarity). Belongs to the borealin family. | 0.999 |
| BIRC5 | CDK1 | ENSPPYP00000009754 | ENSPPYP00000002808 | Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...] | Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, G [...] | 0.989 |
