| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATP5F1B | AURKB | ENSPPYP00000005318 | ENSPPYP00000008941 | ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. | AURKB isoform 2; Belongs to the protein kinase superfamily. | 0.724 |
| ATP5F1B | BIRC5 | ENSPPYP00000005318 | ENSPPYP00000009754 | ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. | Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...] | 0.949 |
| ATP5F1B | CR201_G0041580 | ENSPPYP00000005318 | ENSPPYP00000003662 | ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. | INCENP isoform 2. | 0.920 |
| ATP5F1B | XIAP | ENSPPYP00000005318 | ENSPPYP00000023167 | ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. | XIAP isoform 2. | 0.620 |
| AURKB | ATP5F1B | ENSPPYP00000008941 | ENSPPYP00000005318 | AURKB isoform 2; Belongs to the protein kinase superfamily. | ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. | 0.724 |
| AURKB | BIRC5 | ENSPPYP00000008941 | ENSPPYP00000009754 | AURKB isoform 2; Belongs to the protein kinase superfamily. | Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...] | 0.979 |
| AURKB | CDCA8 | ENSPPYP00000008941 | ENSPPYP00000001762 | AURKB isoform 2; Belongs to the protein kinase superfamily. | Borealin; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA (By similarity). Belongs to the borealin family. | 0.999 |
| AURKB | CDK1 | ENSPPYP00000008941 | ENSPPYP00000002808 | AURKB isoform 2; Belongs to the protein kinase superfamily. | Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, G [...] | 0.963 |
| AURKB | CR201_G0041580 | ENSPPYP00000008941 | ENSPPYP00000003662 | AURKB isoform 2; Belongs to the protein kinase superfamily. | INCENP isoform 2. | 0.999 |
| AURKB | XIAP | ENSPPYP00000008941 | ENSPPYP00000023167 | AURKB isoform 2; Belongs to the protein kinase superfamily. | XIAP isoform 2. | 0.659 |
| BIRC5 | ATP5F1B | ENSPPYP00000009754 | ENSPPYP00000005318 | Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...] | ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. | 0.949 |
| BIRC5 | AURKB | ENSPPYP00000009754 | ENSPPYP00000008941 | Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...] | AURKB isoform 2; Belongs to the protein kinase superfamily. | 0.979 |
| BIRC5 | CASP3 | ENSPPYP00000009754 | ENSPPYP00000017020 | Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...] | CASP3 isoform 1; Belongs to the peptidase C14A family. | 0.953 |
| BIRC5 | CASP7 | ENSPPYP00000009754 | ENSPPYP00000003106 | Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...] | CASP7 isoform 4; Belongs to the peptidase C14A family. | 0.945 |
| BIRC5 | CASP9 | ENSPPYP00000009754 | ENSPPYP00000002138 | Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...] | CASP9 isoform 2; Belongs to the peptidase C14A family. | 0.959 |
| BIRC5 | CDCA8 | ENSPPYP00000009754 | ENSPPYP00000001762 | Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...] | Borealin; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA (By similarity). Belongs to the borealin family. | 0.998 |
| BIRC5 | CDK1 | ENSPPYP00000009754 | ENSPPYP00000002808 | Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...] | Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, G [...] | 0.952 |
| BIRC5 | CR201_G0041580 | ENSPPYP00000009754 | ENSPPYP00000003662 | Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...] | INCENP isoform 2. | 0.981 |
| BIRC5 | DIABLO | ENSPPYP00000009754 | ENSPPYP00000005770 | Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...] | Diablo homolog, mitochondrial; Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP) (By similarity). inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases (By similarity). | 0.983 |
| BIRC5 | XIAP | ENSPPYP00000009754 | ENSPPYP00000023167 | Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...] | XIAP isoform 2. | 0.958 |
STRING v12.5 is now available!
