SOCS3 protein (Pongo abelii) - STRING interaction network

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Score

SOCS3

Suppressor of cytokine signaling 3. (225 aa)

Predicted Functional Partners:

JAK2

0.998

JAK1

0.993

STAT1

0.981

LEPR

0.980

STAT3

0.975

SOCS2

0.960

SOCS1

0.958

CR201_G0047121

0.942

IRS4

0.925

CUL5

0.921

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CR201_G0047121	CUL5	ENSPPYP00000011782	ENSPPYP00000004398	Tyrosine-protein kinase.	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	0.430
CR201_G0047121	IRS4	ENSPPYP00000011782	ENSPPYP00000023087	Tyrosine-protein kinase.	Insulin receptor substrate 4.	0.576
CR201_G0047121	JAK1	ENSPPYP00000011782	ENSPPYP00000001481	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.880
CR201_G0047121	JAK2	ENSPPYP00000011782	ENSPPYP00000021551	Tyrosine-protein kinase.	Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...]	0.981
CR201_G0047121	LEPR	ENSPPYP00000011782	ENSPPYP00000001479	Tyrosine-protein kinase.	Leptin receptor.	0.619
CR201_G0047121	SOCS1	ENSPPYP00000011782	ENSPPYP00000008028	Tyrosine-protein kinase.	Suppressor of cytokine signaling 1.	0.947
CR201_G0047121	SOCS2	ENSPPYP00000011782	ENSPPYP00000005514	Tyrosine-protein kinase.	Suppressor of cytokine signaling 2.	0.411
CR201_G0047121	SOCS3	ENSPPYP00000011782	ENSPPYP00000009756	Tyrosine-protein kinase.	Suppressor of cytokine signaling 3.	0.942
CR201_G0047121	STAT1	ENSPPYP00000011782	ENSPPYP00000014555	Tyrosine-protein kinase.	Signal transducer and activator of transcription.	0.881
CR201_G0047121	STAT3	ENSPPYP00000011782	ENSPPYP00000009437	Tyrosine-protein kinase.	Signal transducer and activator of transcription.	0.890
CUL5	CR201_G0047121	ENSPPYP00000004398	ENSPPYP00000011782	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	Tyrosine-protein kinase.	0.430
CUL5	JAK1	ENSPPYP00000004398	ENSPPYP00000001481	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	Tyrosine-protein kinase.	0.427
CUL5	JAK2	ENSPPYP00000004398	ENSPPYP00000021551	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...]	0.452
CUL5	SOCS1	ENSPPYP00000004398	ENSPPYP00000008028	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	Suppressor of cytokine signaling 1.	0.885
CUL5	SOCS2	ENSPPYP00000004398	ENSPPYP00000005514	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	Suppressor of cytokine signaling 2.	0.977
CUL5	SOCS3	ENSPPYP00000004398	ENSPPYP00000009756	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	Suppressor of cytokine signaling 3.	0.921
IRS4	CR201_G0047121	ENSPPYP00000023087	ENSPPYP00000011782	Insulin receptor substrate 4.	Tyrosine-protein kinase.	0.576
IRS4	JAK1	ENSPPYP00000023087	ENSPPYP00000001481	Insulin receptor substrate 4.	Tyrosine-protein kinase.	0.588
IRS4	JAK2	ENSPPYP00000023087	ENSPPYP00000021551	Insulin receptor substrate 4.	Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...]	0.973
IRS4	SOCS1	ENSPPYP00000023087	ENSPPYP00000008028	Insulin receptor substrate 4.	Suppressor of cytokine signaling 1.	0.928