| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BICC1 | NPTX1 | ENSPPYP00000002817 | ENSPPYP00000009789 | BICC1 isoform 1. | Neuronal pentraxin 1. | 0.564 |
| BRINP2 | NPTX1 | ENSPPYP00000000550 | ENSPPYP00000009789 | BMP/retinoic acid-inducible neural-specific protein 2; Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition; Belongs to the BRINP family. | Neuronal pentraxin 1. | 0.505 |
| EED | NPTX1 | ENSPPYP00000004284 | ENSPPYP00000009789 | Embryonic ectoderm development. | Neuronal pentraxin 1. | 0.509 |
| EED | RING1 | ENSPPYP00000004284 | ENSPPYP00000019327 | Embryonic ectoderm development. | Ring finger protein 1. | 0.915 |
| EED | RNF2 | ENSPPYP00000004284 | ENSPPYP00000000473 | Embryonic ectoderm development. | E3 ubiquitin-protein ligase RING2; E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, i [...] | 0.967 |
| GRIA1 | GRIA2 | ENSPPYP00000017871 | ENSPPYP00000016932 | GRIA1 isoform 7. | Glutamate receptor 2; Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of [...] | 0.999 |
| GRIA1 | NPTX1 | ENSPPYP00000017871 | ENSPPYP00000009789 | GRIA1 isoform 7. | Neuronal pentraxin 1. | 0.500 |
| GRIA2 | GRIA1 | ENSPPYP00000016932 | ENSPPYP00000017871 | Glutamate receptor 2; Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of [...] | GRIA1 isoform 7. | 0.999 |
| GRIA2 | NPTX1 | ENSPPYP00000016932 | ENSPPYP00000009789 | Glutamate receptor 2; Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of [...] | Neuronal pentraxin 1. | 0.633 |
| NIT2 | NPTX1 | ENSPPYP00000015207 | ENSPPYP00000009789 | Omega-amidase NIT2; Has a omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting alpha- ketoglutaramate and alpha-ketosuccinamate to biologically useful alpha- ketoglutarate and oxaloacetate, respectively. Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family. | Neuronal pentraxin 1. | 0.537 |
| NPTX1 | BICC1 | ENSPPYP00000009789 | ENSPPYP00000002817 | Neuronal pentraxin 1. | BICC1 isoform 1. | 0.564 |
| NPTX1 | BRINP2 | ENSPPYP00000009789 | ENSPPYP00000000550 | Neuronal pentraxin 1. | BMP/retinoic acid-inducible neural-specific protein 2; Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition; Belongs to the BRINP family. | 0.505 |
| NPTX1 | EED | ENSPPYP00000009789 | ENSPPYP00000004284 | Neuronal pentraxin 1. | Embryonic ectoderm development. | 0.509 |
| NPTX1 | GRIA1 | ENSPPYP00000009789 | ENSPPYP00000017871 | Neuronal pentraxin 1. | GRIA1 isoform 7. | 0.500 |
| NPTX1 | GRIA2 | ENSPPYP00000009789 | ENSPPYP00000016932 | Neuronal pentraxin 1. | Glutamate receptor 2; Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of [...] | 0.633 |
| NPTX1 | NIT2 | ENSPPYP00000009789 | ENSPPYP00000015207 | Neuronal pentraxin 1. | Omega-amidase NIT2; Has a omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting alpha- ketoglutaramate and alpha-ketosuccinamate to biologically useful alpha- ketoglutarate and oxaloacetate, respectively. Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family. | 0.537 |
| NPTX1 | OPA1 | ENSPPYP00000009789 | ENSPPYP00000016126 | Neuronal pentraxin 1. | Dynamin-like 120 kDa protein, mitochondrial; Dynamin-related GTPase that is essential for normal mitochondrial morphology by regulating the equilibrium between mitochondrial fusion and mitochondrial fission. Binds lipid membranes enriched in negatively charged phospholipids, such as cardiolipin, and promotes membrane tubulation. The intrinsic GTPase activity is low, and is strongly increased by interaction with lipid membranes (By similarity). Plays a role in remodeling cristae and the release of cytochrome c during apoptosis (By similarity). Proteolytic processing in response to intri [...] | 0.630 |
| NPTX1 | RING1 | ENSPPYP00000009789 | ENSPPYP00000019327 | Neuronal pentraxin 1. | Ring finger protein 1. | 0.574 |
| NPTX1 | RNF2 | ENSPPYP00000009789 | ENSPPYP00000000473 | Neuronal pentraxin 1. | E3 ubiquitin-protein ligase RING2; E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, i [...] | 0.574 |
| NPTX1 | SLC30A3 | ENSPPYP00000009789 | ENSPPYP00000014024 | Neuronal pentraxin 1. | Zinc transporter 3; Involved in accumulation of zinc in synaptic vesicles. Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. | 0.502 |
