| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APITD1 | CENPN | ENSPPYP00000002202 | ENSPPYP00000008557 | CENPS isoform 1. | Centromere protein N. | 0.974 |
| APITD1 | CENPX | ENSPPYP00000002202 | ENSPPYP00000009834 | CENPS isoform 1. | Centromere protein X; DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked rep [...] | 0.999 |
| APITD1 | FAAP100 | ENSPPYP00000002202 | ENSPPYP00000009806 | CENPS isoform 1. | FAAP100 isoform 1. | 0.974 |
| APITD1 | FAAP24 | ENSPPYP00000002202 | ENSPPYP00000024336 | CENPS isoform 1. | FAAP24 isoform 3. | 0.978 |
| APITD1 | FANCA | ENSPPYP00000002202 | ENSPPYP00000008650 | CENPS isoform 1. | FANCA isoform 6. | 0.976 |
| APITD1 | FANCC | ENSPPYP00000002202 | ENSPPYP00000021749 | CENPS isoform 1. | Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. | 0.969 |
| APITD1 | FANCF | ENSPPYP00000002202 | ENSPPYP00000003923 | CENPS isoform 1. | FA complementation group F. | 0.970 |
| APITD1 | FANCG | ENSPPYP00000002202 | ENSPPYP00000021407 | CENPS isoform 1. | FA complementation group G. | 0.976 |
| APITD1 | FANCL | ENSPPYP00000002202 | ENSPPYP00000013826 | CENPS isoform 1. | FA complementation group L. | 0.978 |
| APITD1 | FANCM | ENSPPYP00000002202 | ENSPPYP00000006571 | CENPS isoform 1. | FANCM isoform 2. | 0.992 |
| CENPN | APITD1 | ENSPPYP00000008557 | ENSPPYP00000002202 | Centromere protein N. | CENPS isoform 1. | 0.974 |
| CENPN | CENPX | ENSPPYP00000008557 | ENSPPYP00000009834 | Centromere protein N. | Centromere protein X; DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked rep [...] | 0.974 |
| CENPX | APITD1 | ENSPPYP00000009834 | ENSPPYP00000002202 | Centromere protein X; DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked rep [...] | CENPS isoform 1. | 0.999 |
| CENPX | CENPN | ENSPPYP00000009834 | ENSPPYP00000008557 | Centromere protein X; DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked rep [...] | Centromere protein N. | 0.974 |
| CENPX | FAAP100 | ENSPPYP00000009834 | ENSPPYP00000009806 | Centromere protein X; DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked rep [...] | FAAP100 isoform 1. | 0.987 |
| CENPX | FAAP24 | ENSPPYP00000009834 | ENSPPYP00000024336 | Centromere protein X; DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked rep [...] | FAAP24 isoform 3. | 0.989 |
| CENPX | FANCA | ENSPPYP00000009834 | ENSPPYP00000008650 | Centromere protein X; DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked rep [...] | FANCA isoform 6. | 0.979 |
| CENPX | FANCC | ENSPPYP00000009834 | ENSPPYP00000021749 | Centromere protein X; DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked rep [...] | Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. | 0.983 |
| CENPX | FANCF | ENSPPYP00000009834 | ENSPPYP00000003923 | Centromere protein X; DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked rep [...] | FA complementation group F. | 0.984 |
| CENPX | FANCG | ENSPPYP00000009834 | ENSPPYP00000021407 | Centromere protein X; DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked rep [...] | FA complementation group G. | 0.984 |
