STRINGSTRING
VMP1 protein (Pongo abelii) - STRING interaction network
"VMP1" - Vacuole membrane protein 1 in Pongo abelii
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
VMP1Vacuole membrane protein 1; Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Involved in cell-cell adhesion. Plays an essential role in formation of cell junctions. Plays a role in the initial stages of the autophagic process through its interaction with BECN1 (By similarity) (406 aa)    
Predicted Functional Partners:
BECN1
Beclin-1; Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways- PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3- C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Inv [...] (452 aa)
     
  0.938
BECN2
Beclin 2 (441 aa)
     
  0.896
ATG13
Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1- RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity) (517 aa)
         
  0.869
TP53INP2
Tumor protein p53 inducible nuclear protein 2 (212 aa)
         
  0.846
HPGD
15-hydroxyprostaglandin dehydrogenase ; Belongs to the short-chain dehydrogenases/reductases (SDR) family (266 aa)
           
  0.725
FAM63A
Ubiquitin carboxyl-terminal hydrolase MINDY-1; Hydrolase that can specifically remove ’Lys-48’-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover (469 aa)
           
  0.704
EI24
EI24, autophagy associated transmembrane protein; Etoposide induced 2.4 (340 aa)
           
  0.674
EPG5
Ectopic P-granules autophagy protein 5 homolog (C. elegans) (2578 aa)
     
   
  0.668
RAB11FIP1
RAB11 family interacting protein 1 (class I) (1275 aa)
           
  0.666
ZMYND8
Protein kinase C-binding protein 1 (1233 aa)
           
  0.559
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
Server load: low (10%) [HD]