NFE2L1 protein (Pongo abelii) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHCHD4	ENSPPYP00000010045	ENSPPYP00000023518	ENSPPYP00000010045	Coiled-coil-helix-coiled-coil-helix domain containing 4.	annotation not available	0.480
CHCHD4	NFE2L1	ENSPPYP00000023518	ENSPPYP00000009969	Coiled-coil-helix-coiled-coil-helix domain containing 4.	Endoplasmic reticulum membrane sensor NFE2L1; [Endoplasmic reticulum membrane sensor NFE2L1]: Endoplasmic reticulum membrane sensor that translocates into the nucleus in response to various stresses to act as a transcription factor (By similarity). Constitutes a precursor of the transcription factor NRF1 (By similarity). Able to detect various cellular stresses, such as cholesterol excess, oxidative stress or proteasome inhibition (By similarity). In response to stress, it is released from the endoplasmic reticulum membrane following cleavage by the protease DDI2 and translocates into [...]	0.722
CHCHD4	NFE2L3	ENSPPYP00000023518	ENSPPYP00000019859	Coiled-coil-helix-coiled-coil-helix domain containing 4.	Nuclear factor, erythroid 2 like 3.	0.480
ENSPPYP00000010045	CHCHD4	ENSPPYP00000010045	ENSPPYP00000023518	annotation not available	Coiled-coil-helix-coiled-coil-helix domain containing 4.	0.480
ENSPPYP00000010045	KEAP1	ENSPPYP00000010045	ENSPPYP00000010716	annotation not available	Kelch-like ECH-associated protein 1; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination. KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine [...]	0.605
ENSPPYP00000010045	MAFF	ENSPPYP00000010045	ENSPPYP00000013181	annotation not available	MAF bZIP transcription factor F.	0.804
ENSPPYP00000010045	MAFG	ENSPPYP00000010045	ENSPPYP00000009826	annotation not available	MAF bZIP transcription factor G.	0.903
ENSPPYP00000010045	MAFK	ENSPPYP00000010045	ENSPPYP00000019390	annotation not available	MAF bZIP transcription factor K.	0.913
ENSPPYP00000010045	NFE2	ENSPPYP00000010045	ENSPPYP00000005248	annotation not available	NFE2 isoform 1.	0.603
ENSPPYP00000010045	NFE2L1	ENSPPYP00000010045	ENSPPYP00000009969	annotation not available	Endoplasmic reticulum membrane sensor NFE2L1; [Endoplasmic reticulum membrane sensor NFE2L1]: Endoplasmic reticulum membrane sensor that translocates into the nucleus in response to various stresses to act as a transcription factor (By similarity). Constitutes a precursor of the transcription factor NRF1 (By similarity). Able to detect various cellular stresses, such as cholesterol excess, oxidative stress or proteasome inhibition (By similarity). In response to stress, it is released from the endoplasmic reticulum membrane following cleavage by the protease DDI2 and translocates into [...]	0.740
KEAP1	ENSPPYP00000010045	ENSPPYP00000010716	ENSPPYP00000010045	Kelch-like ECH-associated protein 1; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination. KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine [...]	annotation not available	0.605
KEAP1	MAFK	ENSPPYP00000010716	ENSPPYP00000019390	Kelch-like ECH-associated protein 1; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination. KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine [...]	MAF bZIP transcription factor K.	0.429
KEAP1	NFE2	ENSPPYP00000010716	ENSPPYP00000005248	Kelch-like ECH-associated protein 1; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination. KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine [...]	NFE2 isoform 1.	0.776
KEAP1	NFE2L1	ENSPPYP00000010716	ENSPPYP00000009969	Kelch-like ECH-associated protein 1; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination. KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine [...]	Endoplasmic reticulum membrane sensor NFE2L1; [Endoplasmic reticulum membrane sensor NFE2L1]: Endoplasmic reticulum membrane sensor that translocates into the nucleus in response to various stresses to act as a transcription factor (By similarity). Constitutes a precursor of the transcription factor NRF1 (By similarity). Able to detect various cellular stresses, such as cholesterol excess, oxidative stress or proteasome inhibition (By similarity). In response to stress, it is released from the endoplasmic reticulum membrane following cleavage by the protease DDI2 and translocates into [...]	0.945
KEAP1	NFE2L3	ENSPPYP00000010716	ENSPPYP00000019859	Kelch-like ECH-associated protein 1; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination. KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine [...]	Nuclear factor, erythroid 2 like 3.	0.619
MAFF	ENSPPYP00000010045	ENSPPYP00000013181	ENSPPYP00000010045	MAF bZIP transcription factor F.	annotation not available	0.804
MAFF	MAFG	ENSPPYP00000013181	ENSPPYP00000009826	MAF bZIP transcription factor F.	MAF bZIP transcription factor G.	0.827
MAFF	MAFK	ENSPPYP00000013181	ENSPPYP00000019390	MAF bZIP transcription factor F.	MAF bZIP transcription factor K.	0.692
MAFF	NFE2	ENSPPYP00000013181	ENSPPYP00000005248	MAF bZIP transcription factor F.	NFE2 isoform 1.	0.907
MAFF	NFE2L1	ENSPPYP00000013181	ENSPPYP00000009969	MAF bZIP transcription factor F.	Endoplasmic reticulum membrane sensor NFE2L1; [Endoplasmic reticulum membrane sensor NFE2L1]: Endoplasmic reticulum membrane sensor that translocates into the nucleus in response to various stresses to act as a transcription factor (By similarity). Constitutes a precursor of the transcription factor NRF1 (By similarity). Able to detect various cellular stresses, such as cholesterol excess, oxidative stress or proteasome inhibition (By similarity). In response to stress, it is released from the endoplasmic reticulum membrane following cleavage by the protease DDI2 and translocates into [...]	0.929