| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AFG3L2 | PHB | ENSPPYP00000010085 | ENSPPYP00000010009 | AFG3L2 isoform 1. | Prohibitin. | 0.838 |
| AFG3L2 | PHB2 | ENSPPYP00000010085 | ENSPPYP00000004803 | AFG3L2 isoform 1. | Prohibitin-2; Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging (By similarity). In mitochondria, regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration. Binding to sphingoid 1- [...] | 0.853 |
| AFG3L2 | SPG7 | ENSPPYP00000010085 | ENSPPYP00000008641 | AFG3L2 isoform 1. | SPG7 matrix AAA peptidase subunit, paraplegin. | 0.870 |
| AFG3L2 | STOML2 | ENSPPYP00000010085 | ENSPPYP00000021405 | AFG3L2 isoform 1. | STOML2 isoform 3. | 0.543 |
| C1QBP | PHB | ENSPPYP00000008859 | ENSPPYP00000010009 | Complement C1q binding protein. | Prohibitin. | 0.905 |
| C1QBP | PHB2 | ENSPPYP00000008859 | ENSPPYP00000004803 | Complement C1q binding protein. | Prohibitin-2; Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging (By similarity). In mitochondria, regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration. Binding to sphingoid 1- [...] | 0.977 |
| C1QBP | STOML2 | ENSPPYP00000008859 | ENSPPYP00000021405 | Complement C1q binding protein. | STOML2 isoform 3. | 0.590 |
| E2F1 | HDAC1 | ENSPPYP00000012205 | ENSPPYP00000001838 | E2F1 isoform 1. | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | 0.917 |
| E2F1 | PHB | ENSPPYP00000012205 | ENSPPYP00000010009 | E2F1 isoform 1. | Prohibitin. | 0.815 |
| ENSPPYP00000008657 | PHB | ENSPPYP00000008657 | ENSPPYP00000010009 | annotation not available | Prohibitin. | 0.838 |
| ENSPPYP00000008657 | PHB2 | ENSPPYP00000008657 | ENSPPYP00000004803 | annotation not available | Prohibitin-2; Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging (By similarity). In mitochondria, regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration. Binding to sphingoid 1- [...] | 0.853 |
| ENSPPYP00000008657 | SPG7 | ENSPPYP00000008657 | ENSPPYP00000008641 | annotation not available | SPG7 matrix AAA peptidase subunit, paraplegin. | 0.713 |
| ENSPPYP00000008657 | STOML2 | ENSPPYP00000008657 | ENSPPYP00000021405 | annotation not available | STOML2 isoform 3. | 0.543 |
| HDAC1 | E2F1 | ENSPPYP00000001838 | ENSPPYP00000012205 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | E2F1 isoform 1. | 0.917 |
| HDAC1 | PHB | ENSPPYP00000001838 | ENSPPYP00000010009 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | Prohibitin. | 0.829 |
| HDAC1 | PHB2 | ENSPPYP00000001838 | ENSPPYP00000004803 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | Prohibitin-2; Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging (By similarity). In mitochondria, regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration. Binding to sphingoid 1- [...] | 0.776 |
| HDAC1 | STOML2 | ENSPPYP00000001838 | ENSPPYP00000021405 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | STOML2 isoform 3. | 0.540 |
| NDUFS3 | PHB | ENSPPYP00000003782 | ENSPPYP00000010009 | NDUFS3 isoform 1; Belongs to the complex I 30 kDa subunit family. | Prohibitin. | 0.836 |
| NDUFS3 | STOML2 | ENSPPYP00000003782 | ENSPPYP00000021405 | NDUFS3 isoform 1; Belongs to the complex I 30 kDa subunit family. | STOML2 isoform 3. | 0.427 |
| PHB | AFG3L2 | ENSPPYP00000010009 | ENSPPYP00000010085 | Prohibitin. | AFG3L2 isoform 1. | 0.838 |
