| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ALDH18A1 | ATIC | ENSPPYP00000002911 | ENSPPYP00000014690 | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | 0.475 |
| ALDH18A1 | ENSPPYP00000010051 | ENSPPYP00000002911 | ENSPPYP00000010051 | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | annotation not available | 0.916 |
| ALDH18A1 | FPGS | ENSPPYP00000002911 | ENSPPYP00000022000 | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | 0.635 |
| ALDH18A1 | GART | ENSPPYP00000002911 | ENSPPYP00000012701 | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. | 0.777 |
| ALDH18A1 | GLDC | ENSPPYP00000002911 | ENSPPYP00000021533 | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.481 |
| ALDH18A1 | MTHFD1 | ENSPPYP00000002911 | ENSPPYP00000006705 | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | C-1-tetrahydrofolate synthase, cytoplasmic; In the C-terminal section; belongs to the formate-- tetrahydrofolate ligase family. | 0.824 |
| ALDH18A1 | MTHFD1L | ENSPPYP00000002911 | ENSPPYP00000019152 | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | MTHFD1L isoform 1. | 0.824 |
| ALDH18A1 | MTHFR | ENSPPYP00000002911 | ENSPPYP00000002178 | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.564 |
| ALDH18A1 | TYMS | ENSPPYP00000002911 | ENSPPYP00000010155 | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Thymidylate synthetase. | 0.690 |
| ATIC | ALDH18A1 | ENSPPYP00000014690 | ENSPPYP00000002911 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | 0.475 |
| ATIC | ENSPPYP00000010051 | ENSPPYP00000014690 | ENSPPYP00000010051 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | annotation not available | 0.793 |
| ATIC | GART | ENSPPYP00000014690 | ENSPPYP00000012701 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. | 0.999 |
| ATIC | GCSH | ENSPPYP00000014690 | ENSPPYP00000008560 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | 0.542 |
| ATIC | GLDC | ENSPPYP00000014690 | ENSPPYP00000021533 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.655 |
| ATIC | MTHFD1 | ENSPPYP00000014690 | ENSPPYP00000006705 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | C-1-tetrahydrofolate synthase, cytoplasmic; In the C-terminal section; belongs to the formate-- tetrahydrofolate ligase family. | 0.983 |
| ATIC | MTHFD1L | ENSPPYP00000014690 | ENSPPYP00000019152 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | MTHFD1L isoform 1. | 0.983 |
| ATIC | MTHFR | ENSPPYP00000014690 | ENSPPYP00000002178 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.549 |
| ATIC | TYMS | ENSPPYP00000014690 | ENSPPYP00000010155 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | Thymidylate synthetase. | 0.571 |
| ENSPPYP00000010051 | ALDH18A1 | ENSPPYP00000010051 | ENSPPYP00000002911 | annotation not available | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | 0.916 |
| ENSPPYP00000010051 | ATIC | ENSPPYP00000010051 | ENSPPYP00000014690 | annotation not available | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | 0.793 |
