| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MIOS | NPRL2 | ENSPPYP00000019940 | ENSPPYP00000015488 | GATOR complex protein MIOS; As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1. | NPR2 like, GATOR1 complex subunit. | 0.997 |
| MIOS | NPRL3 | ENSPPYP00000019940 | ENSPPYP00000007809 | GATOR complex protein MIOS; As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1. | NPRL3 isoform 6. | 0.997 |
| MIOS | SEC13 | ENSPPYP00000019940 | ENSPPYP00000015269 | GATOR complex protein MIOS; As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1. | SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. | 0.999 |
| MIOS | SEH1L | ENSPPYP00000019940 | ENSPPYP00000010077 | GATOR complex protein MIOS; As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1. | Nucleoporin SEH1; Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore. Belongs to the WD repeat SEC13 family. | 0.999 |
| MIOS | WDR24 | ENSPPYP00000019940 | ENSPPYP00000007839 | GATOR complex protein MIOS; As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1. | WDR24 isoform 1. | 0.999 |
| MIOS | WDR59 | ENSPPYP00000019940 | ENSPPYP00000008526 | GATOR complex protein MIOS; As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1. | WDR59 isoform 2. | 0.999 |
| NPRL2 | MIOS | ENSPPYP00000015488 | ENSPPYP00000019940 | NPR2 like, GATOR1 complex subunit. | GATOR complex protein MIOS; As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1. | 0.997 |
| NPRL2 | NPRL3 | ENSPPYP00000015488 | ENSPPYP00000007809 | NPR2 like, GATOR1 complex subunit. | NPRL3 isoform 6. | 0.999 |
| NPRL2 | SEC13 | ENSPPYP00000015488 | ENSPPYP00000015269 | NPR2 like, GATOR1 complex subunit. | SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. | 0.994 |
| NPRL2 | SEH1L | ENSPPYP00000015488 | ENSPPYP00000010077 | NPR2 like, GATOR1 complex subunit. | Nucleoporin SEH1; Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore. Belongs to the WD repeat SEC13 family. | 0.997 |
| NPRL2 | WDR24 | ENSPPYP00000015488 | ENSPPYP00000007839 | NPR2 like, GATOR1 complex subunit. | WDR24 isoform 1. | 0.998 |
| NPRL2 | WDR59 | ENSPPYP00000015488 | ENSPPYP00000008526 | NPR2 like, GATOR1 complex subunit. | WDR59 isoform 2. | 0.998 |
| NPRL3 | MIOS | ENSPPYP00000007809 | ENSPPYP00000019940 | NPRL3 isoform 6. | GATOR complex protein MIOS; As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1. | 0.997 |
| NPRL3 | NPRL2 | ENSPPYP00000007809 | ENSPPYP00000015488 | NPRL3 isoform 6. | NPR2 like, GATOR1 complex subunit. | 0.999 |
| NPRL3 | SEC13 | ENSPPYP00000007809 | ENSPPYP00000015269 | NPRL3 isoform 6. | SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. | 0.993 |
| NPRL3 | SEH1L | ENSPPYP00000007809 | ENSPPYP00000010077 | NPRL3 isoform 6. | Nucleoporin SEH1; Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore. Belongs to the WD repeat SEC13 family. | 0.993 |
| NPRL3 | WDR24 | ENSPPYP00000007809 | ENSPPYP00000007839 | NPRL3 isoform 6. | WDR24 isoform 1. | 0.999 |
| NPRL3 | WDR59 | ENSPPYP00000007809 | ENSPPYP00000008526 | NPRL3 isoform 6. | WDR59 isoform 2. | 0.997 |
| NUP107 | NUP133 | ENSPPYP00000005413 | ENSPPYP00000000128 | Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). | NUP133 isoform 1. | 0.999 |
| NUP107 | NUP43 | ENSPPYP00000005413 | ENSPPYP00000019137 | Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). | NUP43 isoform 1. | 0.999 |
