PTPN2 protein (Pongo abelii) - STRING interaction network

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Predicted Interactions

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Score

PTPN2

Tyrosine-protein phosphatase non-receptor type. (387 aa)

Predicted Functional Partners:

STAT3

0.989

STAT1

0.981

JAK1

0.965

JAK2

0.962

STAT5A

0.958

STAT5B

0.958

STAT6

0.951

STAT4

0.764

JAK3

0.720

INSRR

0.677

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
INSRR	PTPN2	ENSPPYP00000000809	ENSPPYP00000010078	Tyrosine-protein kinase receptor.	Tyrosine-protein phosphatase non-receptor type.	0.677
JAK1	JAK2	ENSPPYP00000001481	ENSPPYP00000021551	Tyrosine-protein kinase.	Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...]	0.998
JAK1	JAK3	ENSPPYP00000001481	ENSPPYP00000010896	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.983
JAK1	PTPN2	ENSPPYP00000001481	ENSPPYP00000010078	Tyrosine-protein kinase.	Tyrosine-protein phosphatase non-receptor type.	0.965
JAK1	STAT1	ENSPPYP00000001481	ENSPPYP00000014555	Tyrosine-protein kinase.	Signal transducer and activator of transcription.	0.999
JAK1	STAT3	ENSPPYP00000001481	ENSPPYP00000009437	Tyrosine-protein kinase.	Signal transducer and activator of transcription.	0.999
JAK1	STAT4	ENSPPYP00000001481	ENSPPYP00000014556	Tyrosine-protein kinase.	Signal transducer and activator of transcription.	0.845
JAK1	STAT5A	ENSPPYP00000001481	ENSPPYP00000009439	Tyrosine-protein kinase.	Signal transducer and activator of transcription.	0.990
JAK1	STAT5B	ENSPPYP00000001481	ENSPPYP00000009440	Tyrosine-protein kinase.	Signal transducer and activator of transcription.	0.990
JAK1	STAT6	ENSPPYP00000001481	ENSPPYP00000005333	Tyrosine-protein kinase.	Signal transducer and activator of transcription.	0.985
JAK2	JAK1	ENSPPYP00000021551	ENSPPYP00000001481	Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...]	Tyrosine-protein kinase.	0.998
JAK2	JAK3	ENSPPYP00000021551	ENSPPYP00000010896	Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...]	Tyrosine-protein kinase.	0.670
JAK2	PTPN2	ENSPPYP00000021551	ENSPPYP00000010078	Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...]	Tyrosine-protein phosphatase non-receptor type.	0.962
JAK2	STAT1	ENSPPYP00000021551	ENSPPYP00000014555	Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...]	Signal transducer and activator of transcription.	0.997
JAK2	STAT3	ENSPPYP00000021551	ENSPPYP00000009437	Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...]	Signal transducer and activator of transcription.	0.999
JAK2	STAT4	ENSPPYP00000021551	ENSPPYP00000014556	Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...]	Signal transducer and activator of transcription.	0.750
JAK2	STAT5A	ENSPPYP00000021551	ENSPPYP00000009439	Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...]	Signal transducer and activator of transcription.	0.997
JAK2	STAT5B	ENSPPYP00000021551	ENSPPYP00000009440	Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...]	Signal transducer and activator of transcription.	0.995
JAK2	STAT6	ENSPPYP00000021551	ENSPPYP00000005333	Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...]	Signal transducer and activator of transcription.	0.986
JAK3	JAK1	ENSPPYP00000010896	ENSPPYP00000001481	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.983