node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCDC6 | PPP2CB | ENSPPYP00000002812 | ENSPPYP00000020727 | Coiled-coil domain containing 6. | Serine/threonine-protein phosphatase. | 0.431 |
CCDC6 | PPP4C | ENSPPYP00000002812 | ENSPPYP00000008189 | Coiled-coil domain containing 6. | Serine/threonine-protein phosphatase 4 catalytic subunit; Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2- PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphor [...] | 0.857 |
CCDC6 | PPP4R1 | ENSPPYP00000002812 | ENSPPYP00000010108 | Coiled-coil domain containing 6. | PPP4R1 isoform 1. | 0.865 |
PPP2CB | CCDC6 | ENSPPYP00000020727 | ENSPPYP00000002812 | Serine/threonine-protein phosphatase. | Coiled-coil domain containing 6. | 0.431 |
PPP2CB | PPP2R2A | ENSPPYP00000020727 | ENSPPYP00000020683 | Serine/threonine-protein phosphatase. | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. | 0.999 |
PPP2CB | PPP2R2B | ENSPPYP00000020727 | ENSPPYP00000017801 | Serine/threonine-protein phosphatase. | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. | 0.993 |
PPP2CB | PPP2R5A | ENSPPYP00000020727 | ENSPPYP00000000246 | Serine/threonine-protein phosphatase. | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. | 0.986 |
PPP2CB | PPP2R5B | ENSPPYP00000020727 | ENSPPYP00000003575 | Serine/threonine-protein phosphatase. | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. | 0.980 |
PPP2CB | PPP2R5C | ENSPPYP00000020727 | ENSPPYP00000006992 | Serine/threonine-protein phosphatase. | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. | 0.986 |
PPP2CB | PPP2R5D | ENSPPYP00000020727 | ENSPPYP00000018594 | Serine/threonine-protein phosphatase. | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. | 0.998 |
PPP2CB | PPP2R5E | ENSPPYP00000020727 | ENSPPYP00000006695 | Serine/threonine-protein phosphatase. | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. | 0.964 |
PPP2CB | PPP4C | ENSPPYP00000020727 | ENSPPYP00000008189 | Serine/threonine-protein phosphatase. | Serine/threonine-protein phosphatase 4 catalytic subunit; Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2- PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphor [...] | 0.806 |
PPP2CB | PPP4R1 | ENSPPYP00000020727 | ENSPPYP00000010108 | Serine/threonine-protein phosphatase. | PPP4R1 isoform 1. | 0.857 |
PPP2R2A | PPP2CB | ENSPPYP00000020683 | ENSPPYP00000020727 | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. | Serine/threonine-protein phosphatase. | 0.999 |
PPP2R2A | PPP2R2B | ENSPPYP00000020683 | ENSPPYP00000017801 | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. | 0.928 |
PPP2R2A | PPP2R5A | ENSPPYP00000020683 | ENSPPYP00000000246 | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. | 0.840 |
PPP2R2A | PPP2R5B | ENSPPYP00000020683 | ENSPPYP00000003575 | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. | 0.780 |
PPP2R2A | PPP2R5C | ENSPPYP00000020683 | ENSPPYP00000006992 | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. | 0.837 |
PPP2R2A | PPP2R5D | ENSPPYP00000020683 | ENSPPYP00000018594 | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. | 0.816 |
PPP2R2A | PPP2R5E | ENSPPYP00000020683 | ENSPPYP00000006695 | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. | 0.840 |