| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACVR1B | ACVR2B | ENSPPYP00000005175 | ENSPPYP00000015666 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | 0.994 |
| ACVR1B | SMAD2 | ENSPPYP00000005175 | ENSPPYP00000010275 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. | Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] | 0.987 |
| ACVR1B | SMAD3 | ENSPPYP00000005175 | ENSPPYP00000007465 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. | Mothers against decapentaplegic homolog. | 0.980 |
| ACVR1B | SMAD4 | ENSPPYP00000005175 | ENSPPYP00000010297 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. | Mothers against decapentaplegic homolog. | 0.784 |
| ACVR1B | SMAD7 | ENSPPYP00000005175 | ENSPPYP00000010278 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. | Mothers against decapentaplegic homolog. | 0.906 |
| ACVR1B | SMURF2 | ENSPPYP00000005175 | ENSPPYP00000009604 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. | E3 ubiquitin-protein ligase. | 0.720 |
| ACVR1B | TGFBR1 | ENSPPYP00000005175 | ENSPPYP00000021783 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. | 0.608 |
| ACVR1B | TGFBR2 | ENSPPYP00000005175 | ENSPPYP00000015718 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] | 0.873 |
| ACVR1B | ZFYVE9 | ENSPPYP00000005175 | ENSPPYP00000001570 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. | Zinc finger FYVE domain-containing protein. | 0.481 |
| ACVR2B | ACVR1B | ENSPPYP00000015666 | ENSPPYP00000005175 | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. | 0.994 |
| ACVR2B | SMAD2 | ENSPPYP00000015666 | ENSPPYP00000010275 | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] | 0.983 |
| ACVR2B | SMAD3 | ENSPPYP00000015666 | ENSPPYP00000007465 | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | Mothers against decapentaplegic homolog. | 0.975 |
| ACVR2B | SMAD4 | ENSPPYP00000015666 | ENSPPYP00000010297 | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | Mothers against decapentaplegic homolog. | 0.745 |
| ACVR2B | SMAD7 | ENSPPYP00000015666 | ENSPPYP00000010278 | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | Mothers against decapentaplegic homolog. | 0.618 |
| ACVR2B | SMURF2 | ENSPPYP00000015666 | ENSPPYP00000009604 | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | E3 ubiquitin-protein ligase. | 0.519 |
| ACVR2B | TGFBR1 | ENSPPYP00000015666 | ENSPPYP00000021783 | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. | 0.957 |
| ACVR2B | TGFBR2 | ENSPPYP00000015666 | ENSPPYP00000015718 | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] | 0.606 |
| ACVR2B | ZFYVE9 | ENSPPYP00000015666 | ENSPPYP00000001570 | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | Zinc finger FYVE domain-containing protein. | 0.437 |
| MAPK3 | SMAD2 | ENSPPYP00000008184 | ENSPPYP00000010275 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] | 0.983 |
| MAPK3 | SMAD3 | ENSPPYP00000008184 | ENSPPYP00000007465 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | Mothers against decapentaplegic homolog. | 0.975 |
