MAPK4 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

MAPK4

MAPK4 isoform 1. (587 aa)

Predicted Functional Partners:

MAPK6

0.989

MAPKAPK5

0.955

XPO1

0.905

PAK2

0.834

JUN

0.804

FOS

0.782

FOSL1

0.779

FOSB

0.779

MAP2K2

0.638

CDC42

0.624

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC42	MAPK4	ENSPPYP00000002031	ENSPPYP00000010293	Cell division cycle 42.	MAPK4 isoform 1.	0.624
CDC42	MAPK6	ENSPPYP00000002031	ENSPPYP00000007346	Cell division cycle 42.	Mitogen-activated protein kinase 6; Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity); Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase s [...]	0.764
CDC42	PAK2	ENSPPYP00000002031	ENSPPYP00000016156	Cell division cycle 42.	Non-specific serine/threonine protein kinase.	0.999
FOS	FOSB	ENSPPYP00000006826	ENSPPYP00000011320	Fos proto-oncogene, AP-1 transcription factor subunit.	FOSB isoform 8.	0.995
FOS	FOSL1	ENSPPYP00000006826	ENSPPYP00000003519	Fos proto-oncogene, AP-1 transcription factor subunit.	FOSL1 isoform 2.	0.954
FOS	JUN	ENSPPYP00000006826	ENSPPYP00000001511	Fos proto-oncogene, AP-1 transcription factor subunit.	JUN isoform 1; Belongs to the bZIP family.	0.999
FOS	MAPK4	ENSPPYP00000006826	ENSPPYP00000010293	Fos proto-oncogene, AP-1 transcription factor subunit.	MAPK4 isoform 1.	0.782
FOS	MAPK6	ENSPPYP00000006826	ENSPPYP00000007346	Fos proto-oncogene, AP-1 transcription factor subunit.	Mitogen-activated protein kinase 6; Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity); Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase s [...]	0.788
FOSB	FOS	ENSPPYP00000011320	ENSPPYP00000006826	FOSB isoform 8.	Fos proto-oncogene, AP-1 transcription factor subunit.	0.995
FOSB	FOSL1	ENSPPYP00000011320	ENSPPYP00000003519	FOSB isoform 8.	FOSL1 isoform 2.	0.970
FOSB	JUN	ENSPPYP00000011320	ENSPPYP00000001511	FOSB isoform 8.	JUN isoform 1; Belongs to the bZIP family.	0.997
FOSB	MAPK4	ENSPPYP00000011320	ENSPPYP00000010293	FOSB isoform 8.	MAPK4 isoform 1.	0.779
FOSB	MAPK6	ENSPPYP00000011320	ENSPPYP00000007346	FOSB isoform 8.	Mitogen-activated protein kinase 6; Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity); Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase s [...]	0.779
FOSL1	FOS	ENSPPYP00000003519	ENSPPYP00000006826	FOSL1 isoform 2.	Fos proto-oncogene, AP-1 transcription factor subunit.	0.954
FOSL1	FOSB	ENSPPYP00000003519	ENSPPYP00000011320	FOSL1 isoform 2.	FOSB isoform 8.	0.970
FOSL1	JUN	ENSPPYP00000003519	ENSPPYP00000001511	FOSL1 isoform 2.	JUN isoform 1; Belongs to the bZIP family.	0.993
FOSL1	MAPK4	ENSPPYP00000003519	ENSPPYP00000010293	FOSL1 isoform 2.	MAPK4 isoform 1.	0.779
FOSL1	MAPK6	ENSPPYP00000003519	ENSPPYP00000007346	FOSL1 isoform 2.	Mitogen-activated protein kinase 6; Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity); Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase s [...]	0.779
JUN	FOS	ENSPPYP00000001511	ENSPPYP00000006826	JUN isoform 1; Belongs to the bZIP family.	Fos proto-oncogene, AP-1 transcription factor subunit.	0.999
JUN	FOSB	ENSPPYP00000001511	ENSPPYP00000011320	JUN isoform 1; Belongs to the bZIP family.	FOSB isoform 8.	0.997