| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CR201_G0000132 | SKI | ENSPPYP00000006021 | ENSPPYP00000002297 | SMAD1 isoform 8. | SKI isoform 1. | 0.896 |
| CR201_G0000132 | SKIL | ENSPPYP00000006021 | ENSPPYP00000015973 | SMAD1 isoform 8. | Ski-like protein; May have regulatory role in cell division or differentiation in response to extracellular signals. | 0.641 |
| CR201_G0000132 | SMAD2 | ENSPPYP00000006021 | ENSPPYP00000010275 | SMAD1 isoform 8. | Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] | 0.970 |
| CR201_G0000132 | SMAD3 | ENSPPYP00000006021 | ENSPPYP00000007465 | SMAD1 isoform 8. | Mothers against decapentaplegic homolog. | 0.991 |
| CR201_G0000132 | SMAD4 | ENSPPYP00000006021 | ENSPPYP00000010297 | SMAD1 isoform 8. | Mothers against decapentaplegic homolog. | 0.999 |
| CR201_G0000132 | SMAD5 | ENSPPYP00000006021 | ENSPPYP00000017676 | SMAD1 isoform 8. | Mothers against decapentaplegic homolog 5; Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor- regulated SMAD (R-SMAD) (By similarity). | 0.994 |
| CR201_G0000132 | TGFBR1 | ENSPPYP00000006021 | ENSPPYP00000021783 | SMAD1 isoform 8. | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. | 0.704 |
| CR201_G0000132 | TGFBR2 | ENSPPYP00000006021 | ENSPPYP00000015718 | SMAD1 isoform 8. | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] | 0.546 |
| HDAC1 | SKI | ENSPPYP00000001838 | ENSPPYP00000002297 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | SKI isoform 1. | 0.925 |
| HDAC1 | SKIL | ENSPPYP00000001838 | ENSPPYP00000015973 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | Ski-like protein; May have regulatory role in cell division or differentiation in response to extracellular signals. | 0.907 |
| HDAC1 | SMAD2 | ENSPPYP00000001838 | ENSPPYP00000010275 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] | 0.889 |
| HDAC1 | SMAD3 | ENSPPYP00000001838 | ENSPPYP00000007465 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | Mothers against decapentaplegic homolog. | 0.787 |
| HDAC1 | SMAD4 | ENSPPYP00000001838 | ENSPPYP00000010297 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | Mothers against decapentaplegic homolog. | 0.985 |
| HDAC1 | TRIM33 | ENSPPYP00000001838 | ENSPPYP00000001169 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | Tripartite motif containing 33. | 0.432 |
| SKI | CR201_G0000132 | ENSPPYP00000002297 | ENSPPYP00000006021 | SKI isoform 1. | SMAD1 isoform 8. | 0.896 |
| SKI | HDAC1 | ENSPPYP00000002297 | ENSPPYP00000001838 | SKI isoform 1. | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | 0.925 |
| SKI | SKIL | ENSPPYP00000002297 | ENSPPYP00000015973 | SKI isoform 1. | Ski-like protein; May have regulatory role in cell division or differentiation in response to extracellular signals. | 0.995 |
| SKI | SMAD2 | ENSPPYP00000002297 | ENSPPYP00000010275 | SKI isoform 1. | Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] | 0.962 |
| SKI | SMAD3 | ENSPPYP00000002297 | ENSPPYP00000007465 | SKI isoform 1. | Mothers against decapentaplegic homolog. | 0.969 |
| SKI | SMAD4 | ENSPPYP00000002297 | ENSPPYP00000010297 | SKI isoform 1. | Mothers against decapentaplegic homolog. | 0.998 |
