POLI protein (Pongo abelii) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

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[Homology]

Score

POLI

POLI isoform 1. (660 aa)

Predicted Functional Partners:

PCNA

0.972

UBC

0.959

REV1

0.937

WRN

0.912

TP53

0.891

REV3L

0.887

MAD2L2

0.873

UBA52

0.800

SIRT7

0.756

POLD1

0.752

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MAD2L2	PCNA	ENSPPYP00000002184	ENSPPYP00000012059	Mitotic arrest deficient 2 like 2.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.776
MAD2L2	POLD1	ENSPPYP00000002184	ENSPPYP00000011511	Mitotic arrest deficient 2 like 2.	DNA polymerase delta catalytic subunit.	0.898
MAD2L2	POLI	ENSPPYP00000002184	ENSPPYP00000010300	Mitotic arrest deficient 2 like 2.	POLI isoform 1.	0.873
MAD2L2	REV1	ENSPPYP00000002184	ENSPPYP00000013486	Mitotic arrest deficient 2 like 2.	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents (By similarity); Belongs to the DNA polymerase type-Y family.	0.998
MAD2L2	REV3L	ENSPPYP00000002184	ENSPPYP00000018949	Mitotic arrest deficient 2 like 2.	REV3L isoform 3.	0.999
MAD2L2	UBC	ENSPPYP00000002184	ENSPPYP00000005811	Mitotic arrest deficient 2 like 2.	UBC isoform 2.	0.585
PCNA	MAD2L2	ENSPPYP00000012059	ENSPPYP00000002184	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Mitotic arrest deficient 2 like 2.	0.776
PCNA	POLD1	ENSPPYP00000012059	ENSPPYP00000011511	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	DNA polymerase delta catalytic subunit.	0.981
PCNA	POLI	ENSPPYP00000012059	ENSPPYP00000010300	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	POLI isoform 1.	0.972
PCNA	REV1	ENSPPYP00000012059	ENSPPYP00000013486	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents (By similarity); Belongs to the DNA polymerase type-Y family.	0.944
PCNA	REV3L	ENSPPYP00000012059	ENSPPYP00000018949	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	REV3L isoform 3.	0.927
PCNA	TP53	ENSPPYP00000012059	ENSPPYP00000008923	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.825
PCNA	UBA52	ENSPPYP00000012059	ENSPPYP00000010917	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	UBA52 isoform 10.	0.859
PCNA	UBC	ENSPPYP00000012059	ENSPPYP00000005811	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	UBC isoform 2.	0.951
PCNA	WRN	ENSPPYP00000012059	ENSPPYP00000020730	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	WRN isoform 1.	0.984
POLD1	MAD2L2	ENSPPYP00000011511	ENSPPYP00000002184	DNA polymerase delta catalytic subunit.	Mitotic arrest deficient 2 like 2.	0.898
POLD1	PCNA	ENSPPYP00000011511	ENSPPYP00000012059	DNA polymerase delta catalytic subunit.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.981
POLD1	POLI	ENSPPYP00000011511	ENSPPYP00000010300	DNA polymerase delta catalytic subunit.	POLI isoform 1.	0.752
POLD1	REV1	ENSPPYP00000011511	ENSPPYP00000013486	DNA polymerase delta catalytic subunit.	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents (By similarity); Belongs to the DNA polymerase type-Y family.	0.734
POLD1	REV3L	ENSPPYP00000011511	ENSPPYP00000018949	DNA polymerase delta catalytic subunit.	REV3L isoform 3.	0.801