NEDD4L protein (Pongo abelii) - STRING interaction network

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NEDD4L

E3 ubiquitin-protein ligase NEDD4-like; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF- beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, KCNH2, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiq [...] (964 aa)

Predicted Functional Partners:

SGK1

0.997

SCNN1A

0.996

SMAD7

0.996

SCNN1G

0.990

SMAD3

0.984

AMOT

0.953

SMURF2

0.951

UBC

0.949

NEDD4

0.947

TRAF6

0.931

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMOT	NEDD4	ENSPPYP00000023108	ENSPPYP00000007372	AMOT isoform 3.	E3 ubiquitin-protein ligase.	0.532
AMOT	NEDD4L	ENSPPYP00000023108	ENSPPYP00000010317	AMOT isoform 3.	E3 ubiquitin-protein ligase NEDD4-like; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF- beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, KCNH2, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiq [...]	0.953
NEDD4	AMOT	ENSPPYP00000007372	ENSPPYP00000023108	E3 ubiquitin-protein ligase.	AMOT isoform 3.	0.532
NEDD4	NEDD4L	ENSPPYP00000007372	ENSPPYP00000010317	E3 ubiquitin-protein ligase.	E3 ubiquitin-protein ligase NEDD4-like; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF- beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, KCNH2, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiq [...]	0.947
NEDD4	SCNN1A	ENSPPYP00000007372	ENSPPYP00000004767	E3 ubiquitin-protein ligase.	SCNN1A isoform 1; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.	0.949
NEDD4	SCNN1G	ENSPPYP00000007372	ENSPPYP00000008126	E3 ubiquitin-protein ligase.	Sodium channel epithelial 1 gamma subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.	0.939
NEDD4	SGK1	ENSPPYP00000007372	ENSPPYP00000019064	E3 ubiquitin-protein ligase.	Non-specific serine/threonine protein kinase.	0.793
NEDD4	SMAD3	ENSPPYP00000007372	ENSPPYP00000007465	E3 ubiquitin-protein ligase.	Mothers against decapentaplegic homolog.	0.794
NEDD4	SMAD7	ENSPPYP00000007372	ENSPPYP00000010278	E3 ubiquitin-protein ligase.	Mothers against decapentaplegic homolog.	0.789
NEDD4	SMURF2	ENSPPYP00000007372	ENSPPYP00000009604	E3 ubiquitin-protein ligase.	E3 ubiquitin-protein ligase.	0.959
NEDD4	TRAF6	ENSPPYP00000007372	ENSPPYP00000003845	E3 ubiquitin-protein ligase.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.941
NEDD4	UBC	ENSPPYP00000007372	ENSPPYP00000005811	E3 ubiquitin-protein ligase.	UBC isoform 2.	0.949
NEDD4L	AMOT	ENSPPYP00000010317	ENSPPYP00000023108	E3 ubiquitin-protein ligase NEDD4-like; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF- beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, KCNH2, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiq [...]	AMOT isoform 3.	0.953
NEDD4L	NEDD4	ENSPPYP00000010317	ENSPPYP00000007372	E3 ubiquitin-protein ligase NEDD4-like; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF- beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, KCNH2, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiq [...]	E3 ubiquitin-protein ligase.	0.947
NEDD4L	SCNN1A	ENSPPYP00000010317	ENSPPYP00000004767	E3 ubiquitin-protein ligase NEDD4-like; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF- beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, KCNH2, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiq [...]	SCNN1A isoform 1; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.	0.996
NEDD4L	SCNN1G	ENSPPYP00000010317	ENSPPYP00000008126	E3 ubiquitin-protein ligase NEDD4-like; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF- beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, KCNH2, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiq [...]	Sodium channel epithelial 1 gamma subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.	0.990
NEDD4L	SGK1	ENSPPYP00000010317	ENSPPYP00000019064	E3 ubiquitin-protein ligase NEDD4-like; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF- beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, KCNH2, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiq [...]	Non-specific serine/threonine protein kinase.	0.997
NEDD4L	SMAD3	ENSPPYP00000010317	ENSPPYP00000007465	E3 ubiquitin-protein ligase NEDD4-like; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF- beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, KCNH2, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiq [...]	Mothers against decapentaplegic homolog.	0.984
NEDD4L	SMAD7	ENSPPYP00000010317	ENSPPYP00000010278	E3 ubiquitin-protein ligase NEDD4-like; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF- beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, KCNH2, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiq [...]	Mothers against decapentaplegic homolog.	0.996
NEDD4L	SMURF2	ENSPPYP00000010317	ENSPPYP00000009604	E3 ubiquitin-protein ligase NEDD4-like; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF- beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, KCNH2, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiq [...]	E3 ubiquitin-protein ligase.	0.951

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