| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BRIX1 | CR201_G0052501 | ENSPPYP00000017190 | ENSPPYP00000010455 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. Belongs to the BRX1 family. | Guanidinoacetate N-methyltransferase; Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family. | 0.734 |
| BRIX1 | GTPBP4 | ENSPPYP00000017190 | ENSPPYP00000002356 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. Belongs to the BRX1 family. | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. | 0.975 |
| BRIX1 | RPF2 | ENSPPYP00000017190 | ENSPPYP00000018947 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. Belongs to the BRX1 family. | Ribosome production factor 2 homolog. | 0.988 |
| CKM | CKMT2 | ENSPPYP00000011314 | ENSPPYP00000017443 | CKM isoform 1; Belongs to the ATP:guanido phosphotransferase family. | Creatine kinase S-type, mitochondrial; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (By similarity). | 0.479 |
| CKM | CR201_G0052501 | ENSPPYP00000011314 | ENSPPYP00000010455 | CKM isoform 1; Belongs to the ATP:guanido phosphotransferase family. | Guanidinoacetate N-methyltransferase; Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family. | 0.940 |
| CKM | GATM | ENSPPYP00000011314 | ENSPPYP00000007301 | CKM isoform 1; Belongs to the ATP:guanido phosphotransferase family. | Glycine amidinotransferase, mitochondrial; Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development (By similarity). | 0.460 |
| CKM | LOC100432695 | ENSPPYP00000011314 | ENSPPYP00000007272 | CKM isoform 1; Belongs to the ATP:guanido phosphotransferase family. | CKMT1A isoform 1; Belongs to the ATP:guanido phosphotransferase family. | 0.761 |
| CKM | LOC100435206 | ENSPPYP00000011314 | ENSPPYP00000023916 | CKM isoform 1; Belongs to the ATP:guanido phosphotransferase family. | Uncharacterized protein; Belongs to the ATP:guanido phosphotransferase family. | 0.761 |
| CKM | SLC6A8 | ENSPPYP00000011314 | ENSPPYP00000023333 | CKM isoform 1; Belongs to the ATP:guanido phosphotransferase family. | Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. | 0.444 |
| CKMT2 | CKM | ENSPPYP00000017443 | ENSPPYP00000011314 | Creatine kinase S-type, mitochondrial; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (By similarity). | CKM isoform 1; Belongs to the ATP:guanido phosphotransferase family. | 0.479 |
| CKMT2 | CR201_G0052501 | ENSPPYP00000017443 | ENSPPYP00000010455 | Creatine kinase S-type, mitochondrial; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (By similarity). | Guanidinoacetate N-methyltransferase; Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family. | 0.934 |
| CKMT2 | GATM | ENSPPYP00000017443 | ENSPPYP00000007301 | Creatine kinase S-type, mitochondrial; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (By similarity). | Glycine amidinotransferase, mitochondrial; Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development (By similarity). | 0.456 |
| CKMT2 | LOC100432695 | ENSPPYP00000017443 | ENSPPYP00000007272 | Creatine kinase S-type, mitochondrial; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (By similarity). | CKMT1A isoform 1; Belongs to the ATP:guanido phosphotransferase family. | 0.961 |
| CKMT2 | LOC100435206 | ENSPPYP00000017443 | ENSPPYP00000023916 | Creatine kinase S-type, mitochondrial; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (By similarity). | Uncharacterized protein; Belongs to the ATP:guanido phosphotransferase family. | 0.961 |
| CR201_G0052501 | BRIX1 | ENSPPYP00000010455 | ENSPPYP00000017190 | Guanidinoacetate N-methyltransferase; Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family. | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. Belongs to the BRX1 family. | 0.734 |
| CR201_G0052501 | CKM | ENSPPYP00000010455 | ENSPPYP00000011314 | Guanidinoacetate N-methyltransferase; Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family. | CKM isoform 1; Belongs to the ATP:guanido phosphotransferase family. | 0.940 |
| CR201_G0052501 | CKMT2 | ENSPPYP00000010455 | ENSPPYP00000017443 | Guanidinoacetate N-methyltransferase; Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family. | Creatine kinase S-type, mitochondrial; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (By similarity). | 0.934 |
| CR201_G0052501 | GATM | ENSPPYP00000010455 | ENSPPYP00000007301 | Guanidinoacetate N-methyltransferase; Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family. | Glycine amidinotransferase, mitochondrial; Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development (By similarity). | 0.977 |
| CR201_G0052501 | GTPBP4 | ENSPPYP00000010455 | ENSPPYP00000002356 | Guanidinoacetate N-methyltransferase; Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family. | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. | 0.714 |
| CR201_G0052501 | LOC100432695 | ENSPPYP00000010455 | ENSPPYP00000007272 | Guanidinoacetate N-methyltransferase; Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family. | CKMT1A isoform 1; Belongs to the ATP:guanido phosphotransferase family. | 0.933 |
