TCF3 protein (Pongo abelii) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

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co-expression

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[Homology]

Score

TCF3

TCF3 isoform 5. (603 aa)

Predicted Functional Partners:

TAL1

0.977

CTNNB1

0.971

LYL1

0.966

ID2

0.956

ID3

0.954

MYOG

0.953

ID1

0.952

TCF4

0.944

MYOD1

0.937

TWIST1

0.924

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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structured XML interaction data, according to the 'PSI-MI' data standard

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... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTNNB1	MYOD1	ENSPPYP00000015644	ENSPPYP00000003961	CTNNB1 isoform 2.	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	0.407
CTNNB1	TCF3	ENSPPYP00000015644	ENSPPYP00000010467	CTNNB1 isoform 2.	TCF3 isoform 5.	0.971
CTNNB1	TCF4	ENSPPYP00000015644	ENSPPYP00000010306	CTNNB1 isoform 2.	TCF4 isoform 16.	0.970
CTNNB1	TWIST1	ENSPPYP00000015644	ENSPPYP00000019900	CTNNB1 isoform 2.	Twist family bHLH transcription factor 1.	0.518
ID1	ID3	ENSPPYP00000012162	ENSPPYP00000002013	Inhibitor of DNA binding 1, HLH protein.	Inhibitor of DNA binding 3, HLH protein.	0.671
ID1	MYOD1	ENSPPYP00000012162	ENSPPYP00000003961	Inhibitor of DNA binding 1, HLH protein.	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	0.931
ID1	MYOG	ENSPPYP00000012162	ENSPPYP00000000374	Inhibitor of DNA binding 1, HLH protein.	MYOG isoform 1.	0.660
ID1	TCF3	ENSPPYP00000012162	ENSPPYP00000010467	Inhibitor of DNA binding 1, HLH protein.	TCF3 isoform 5.	0.952
ID1	TCF4	ENSPPYP00000012162	ENSPPYP00000010306	Inhibitor of DNA binding 1, HLH protein.	TCF4 isoform 16.	0.884
ID2	MYOD1	ENSPPYP00000014197	ENSPPYP00000003961	DNA-binding protein inhibitor ID-2; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the C [...]	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	0.679
ID2	MYOG	ENSPPYP00000014197	ENSPPYP00000000374	DNA-binding protein inhibitor ID-2; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the C [...]	MYOG isoform 1.	0.712
ID2	TAL1	ENSPPYP00000014197	ENSPPYP00000001602	DNA-binding protein inhibitor ID-2; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the C [...]	TAL1 isoform 1.	0.463
ID2	TCF3	ENSPPYP00000014197	ENSPPYP00000010467	DNA-binding protein inhibitor ID-2; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the C [...]	TCF3 isoform 5.	0.956
ID2	TCF4	ENSPPYP00000014197	ENSPPYP00000010306	DNA-binding protein inhibitor ID-2; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the C [...]	TCF4 isoform 16.	0.934
ID3	ID1	ENSPPYP00000002013	ENSPPYP00000012162	Inhibitor of DNA binding 3, HLH protein.	Inhibitor of DNA binding 1, HLH protein.	0.671
ID3	TCF3	ENSPPYP00000002013	ENSPPYP00000010467	Inhibitor of DNA binding 3, HLH protein.	TCF3 isoform 5.	0.954
ID3	TCF4	ENSPPYP00000002013	ENSPPYP00000010306	Inhibitor of DNA binding 3, HLH protein.	TCF4 isoform 16.	0.835
LYL1	TAL1	ENSPPYP00000010785	ENSPPYP00000001602	LYL1 basic helix-loop-helix family member.	TAL1 isoform 1.	0.515
LYL1	TCF3	ENSPPYP00000010785	ENSPPYP00000010467	LYL1 basic helix-loop-helix family member.	TCF3 isoform 5.	0.966
LYL1	TCF4	ENSPPYP00000010785	ENSPPYP00000010306	LYL1 basic helix-loop-helix family member.	TCF4 isoform 16.	0.506