FZR1 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

FZR1

FZR1 isoform 4. (420 aa)

Predicted Functional Partners:

CDC27

0.999

ANAPC2

0.999

ANAPC5

0.998

PLK1

0.997

NEK2

0.996

TRIM33

0.987

CCNB1

0.986

PTTG1

0.983

CDC16

0.973

CDC23

0.973

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANAPC2	ANAPC5	ENSPPYP00000022215	ENSPPYP00000005751	Anaphase promoting complex subunit 2; Belongs to the cullin family.	Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).	0.999
ANAPC2	CCNB1	ENSPPYP00000022215	ENSPPYP00000017345	Anaphase promoting complex subunit 2; Belongs to the cullin family.	CCNB1 isoform 1; Belongs to the cyclin family.	0.947
ANAPC2	CDC16	ENSPPYP00000022215	ENSPPYP00000006309	Anaphase promoting complex subunit 2; Belongs to the cullin family.	CDC16 isoform 4.	0.999
ANAPC2	CDC23	ENSPPYP00000022215	ENSPPYP00000017692	Anaphase promoting complex subunit 2; Belongs to the cullin family.	Cell division cycle 23.	0.999
ANAPC2	CDC27	ENSPPYP00000022215	ENSPPYP00000010040	Anaphase promoting complex subunit 2; Belongs to the cullin family.	CDC27 isoform 1.	0.999
ANAPC2	FZR1	ENSPPYP00000022215	ENSPPYP00000010515	Anaphase promoting complex subunit 2; Belongs to the cullin family.	FZR1 isoform 4.	0.999
ANAPC2	NEK2	ENSPPYP00000022215	ENSPPYP00000000250	Anaphase promoting complex subunit 2; Belongs to the cullin family.	NIMA related kinase 2.	0.947
ANAPC2	PLK1	ENSPPYP00000022215	ENSPPYP00000008136	Anaphase promoting complex subunit 2; Belongs to the cullin family.	Serine/threonine-protein kinase PLK.	0.525
ANAPC2	PTTG1	ENSPPYP00000022215	ENSPPYP00000017915	Anaphase promoting complex subunit 2; Belongs to the cullin family.	PTTG1 regulator of sister chromatid separation, securin.	0.964
ANAPC5	ANAPC2	ENSPPYP00000005751	ENSPPYP00000022215	Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).	Anaphase promoting complex subunit 2; Belongs to the cullin family.	0.999
ANAPC5	CCNB1	ENSPPYP00000005751	ENSPPYP00000017345	Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).	CCNB1 isoform 1; Belongs to the cyclin family.	0.946
ANAPC5	CDC16	ENSPPYP00000005751	ENSPPYP00000006309	Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).	CDC16 isoform 4.	0.999
ANAPC5	CDC23	ENSPPYP00000005751	ENSPPYP00000017692	Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).	Cell division cycle 23.	0.999
ANAPC5	CDC27	ENSPPYP00000005751	ENSPPYP00000010040	Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).	CDC27 isoform 1.	0.999
ANAPC5	FZR1	ENSPPYP00000005751	ENSPPYP00000010515	Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).	FZR1 isoform 4.	0.998
ANAPC5	NEK2	ENSPPYP00000005751	ENSPPYP00000000250	Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).	NIMA related kinase 2.	0.939
ANAPC5	PLK1	ENSPPYP00000005751	ENSPPYP00000008136	Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).	Serine/threonine-protein kinase PLK.	0.550
ANAPC5	PTTG1	ENSPPYP00000005751	ENSPPYP00000017915	Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).	PTTG1 regulator of sister chromatid separation, securin.	0.962
ANAPC5	TRIM33	ENSPPYP00000005751	ENSPPYP00000001169	Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).	Tripartite motif containing 33.	0.987
CCNB1	ANAPC2	ENSPPYP00000017345	ENSPPYP00000022215	CCNB1 isoform 1; Belongs to the cyclin family.	Anaphase promoting complex subunit 2; Belongs to the cullin family.	0.947