| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CR201_G0007169 | CR201_G0021362 | ENSPPYP00000000742 | ENSPPYP00000020349 | SUMO1 isoform 5. | SUMO2 isoform 4. | 0.586 |
| CR201_G0007169 | ENSPPYP00000009997 | ENSPPYP00000000742 | ENSPPYP00000009997 | SUMO1 isoform 5. | annotation not available | 0.586 |
| CR201_G0007169 | PIAS4 | ENSPPYP00000000742 | ENSPPYP00000010535 | SUMO1 isoform 5. | PIAS4 isoform 1. | 0.989 |
| CR201_G0007169 | RNF168 | ENSPPYP00000000742 | ENSPPYP00000016150 | SUMO1 isoform 5. | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] | 0.544 |
| CR201_G0007169 | STAT1 | ENSPPYP00000000742 | ENSPPYP00000014555 | SUMO1 isoform 5. | Signal transducer and activator of transcription. | 0.408 |
| CR201_G0007169 | SUMO1 | ENSPPYP00000000742 | ENSPPYP00000014619 | SUMO1 isoform 5. | Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for insta [...] | 0.801 |
| CR201_G0007169 | SUMO3 | ENSPPYP00000000742 | ENSPPYP00000012841 | SUMO1 isoform 5. | Small ubiquitin-related modifier. | 0.586 |
| CR201_G0007169 | TP53 | ENSPPYP00000000742 | ENSPPYP00000008923 | SUMO1 isoform 5. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.982 |
| CR201_G0007169 | UBE2I | ENSPPYP00000000742 | ENSPPYP00000007864 | SUMO1 isoform 5. | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. | 0.978 |
| CR201_G0021362 | CR201_G0007169 | ENSPPYP00000020349 | ENSPPYP00000000742 | SUMO2 isoform 4. | SUMO1 isoform 5. | 0.586 |
| CR201_G0021362 | PIAS4 | ENSPPYP00000020349 | ENSPPYP00000010535 | SUMO2 isoform 4. | PIAS4 isoform 1. | 0.982 |
| CR201_G0021362 | RNF168 | ENSPPYP00000020349 | ENSPPYP00000016150 | SUMO2 isoform 4. | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] | 0.461 |
| CR201_G0021362 | SUMO1 | ENSPPYP00000020349 | ENSPPYP00000014619 | SUMO2 isoform 4. | Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for insta [...] | 0.586 |
| CR201_G0021362 | TP53 | ENSPPYP00000020349 | ENSPPYP00000008923 | SUMO2 isoform 4. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.941 |
| CR201_G0021362 | UBE2I | ENSPPYP00000020349 | ENSPPYP00000007864 | SUMO2 isoform 4. | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. | 0.907 |
| ENSPPYP00000009997 | CR201_G0007169 | ENSPPYP00000009997 | ENSPPYP00000000742 | annotation not available | SUMO1 isoform 5. | 0.586 |
| ENSPPYP00000009997 | PIAS4 | ENSPPYP00000009997 | ENSPPYP00000010535 | annotation not available | PIAS4 isoform 1. | 0.982 |
| ENSPPYP00000009997 | RNF168 | ENSPPYP00000009997 | ENSPPYP00000016150 | annotation not available | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] | 0.461 |
| ENSPPYP00000009997 | SUMO1 | ENSPPYP00000009997 | ENSPPYP00000014619 | annotation not available | Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for insta [...] | 0.586 |
| ENSPPYP00000009997 | TP53 | ENSPPYP00000009997 | ENSPPYP00000008923 | annotation not available | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.941 |
